Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jan 2;84(1):9-16.
doi: 10.1158/0008-5472.CAN-23-1290.

Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

Louise Ramos  1   2 , Martin Henriksson  3 , Thomas Helleday  1   3 , Alanna C Green  1   4
Affiliations
Free article
Review

Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

Louise Ramos et al. Cancer Res. .
Free article

Abstract

The one-carbon folate enzyme methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (MTHFD2) is a promising therapeutic target in cancer. MTHFD2 is upregulated across numerous cancer types, promotes growth and metastasis of cancer, and correlates with poorer survival. Recent studies have developed small-molecule inhibitors to the isozymes MTHFD2 and MTHFD1 that show promise as anticancer agents through different mechanisms. This review discusses the current understanding of the function of MTHFD2 in cancer and the status of inhibitors for treating MTHFD2-overexpressing cancers.

PubMed Disclaimer

MeSH terms

Substances