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. 2023 Nov 2;83(21):3758-3760.
doi: 10.1016/j.molcel.2023.10.009.

A domain of all trades: The enzymatic versatility of the NiRAN domain

Adam Osinski  1 , Vincent S Tagliabracci  2
Affiliations
Free article

A domain of all trades: The enzymatic versatility of the NiRAN domain

Adam Osinski et al. Mol Cell. .
Free article

Abstract

The SARS-CoV-2 NiRAN domain is essential for viral replication. Despite adopting a pseudokinase fold, it catalyzes three distinct biochemical reactions from a single active site. In this issue of Molecular Cell, Small et al.1 elucidate the structural intricacies of the NiRAN domain shedding light on the factors that underlie its remarkable versatility.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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