Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Apr;47(2):100676.
doi: 10.1016/j.bj.2023.100676. Epub 2023 Nov 3.

Lifestyle interventions to delay senescence

Jan Martel  1 , David M Ojcius  2 , John D Young  3
Affiliations
Review

Lifestyle interventions to delay senescence

Jan Martel et al. Biomed J. 2024 Apr.

Abstract

Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body. While several compounds described as senolytics and senomorphics produce health benefits by reducing the burden of senescence, less attention has been devoted to lifestyle interventions that produce similar effects. We describe here the effects of exercise, nutrition, caloric restriction, intermittent fasting, phytochemicals from natural products, prebiotics and probiotics, and adequate sleep on senescence in model organisms and humans. These interventions can be integrated within a healthy lifestyle to reduce senescence and inflammation and delay the consequences of aging.

Keywords: Caloric restriction; Exercise; Metformin; Nutrition; Phytochemicals; Senescence.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Characteristics of senescent cells and examples of stresses that increase senescence in the human body. (A) Characteristics and roles of senescent cells. (B) Stresses and lifestyle habits that increase the senescence burden.
Fig. 2
Fig. 2
Lifestyle interventions to delay senescence. The formation and accumulation of senescent cells can be reduced by various lifestyle interventions that can improve health and longevity, mainly by reducing inflammation.
See this image and copyright information in PMC

References

    1. Di Micco R, Krizhanovsky V, Baker D, d’Adda di Fagagna F. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol. 2021;22(2):75–95. - PMC - PubMed
    1. Campisi J, d’Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007;8(9) 729–40. - PubMed
    1. Maeda M, Hayashi T, Mizuno N, Hattori Y, Kuzuya M. Intermittent high glucose implements stress-induced senescence in human vascular endothelial cells: role of superoxide production by NADPH oxidase. PLoS One. 2015;10(4) - PMC - PubMed
    1. Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Kruger P, Fielder E, et al. Obesity-induced cellular senescence drives anxiety and impairs neurogenesis. Cell Metabol. 2019;29(5) 1061–77. - PMC - PubMed
    1. Nyunoya T, Monick MM, Klingelhutz A, Yarovinsky TO, Cagley JR, Hunninghake G.W. Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol. 2006;35(6) 681–8. - PMC - PubMed

Publication types