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Review
. 2023 Oct 20:15:1287322.
doi: 10.3389/fnagi.2023.1287322. eCollection 2023.

Shared genetic architecture of COVID-19 and Alzheimer's disease

Natalia Matveeva  1   2 , Ivan Kiselev  1   2 , Natalia Baulina  1   2 , Ekaterina Semina  1 , Viktor Kakotkin  1 , Mikhail Agapov  1 , Olga Kulakova  1   2 , Olga Favorova  1   2
Affiliations
Review

Shared genetic architecture of COVID-19 and Alzheimer's disease

Natalia Matveeva et al. Front Aging Neurosci. .

Abstract

The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the сoronavirus disease 2019 (COVID-19) have become a global health threat. At the height of the pandemic, major efforts were focused on reducing COVID-19-associated morbidity and mortality. Now is the time to study the long-term effects of the pandemic, particularly cognitive impairment associated with long COVID. In recent years much attention has been paid to the possible relationship between COVID-19 and Alzheimer's disease, which is considered a main cause of age-related cognitive impairment. Genetic predisposition was shown for both COVID-19 and Alzheimer's disease. However, the analysis of the similarity of the genetic architecture of these diseases is usually limited to indicating a positive genetic correlation between them. In this review, we have described intrinsic linkages between COVID-19 and Alzheimer's disease, pointed out shared susceptibility genes that were previously identified in genome-wide association studies of both COVID-19 and Alzheimer's disease, and highlighted a panel of SNPs that includes candidate genetic risk markers of the long COVID-associated cognitive impairment.

Keywords: Alzheimer’s disease; COVID-19; GWAS; SNP; cognitive impairment; genetic susceptibility; long Covid; pathway analysis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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