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Editorial
. 2023 Oct 13:17:1296958.
doi: 10.3389/fncel.2023.1296958. eCollection 2023.

Editorial: Tubulinopathies: fundamental and clinical challenges

Antonella Sferra  1 , Enrico Bertini  1 , Georg Haase  2
Affiliations
Editorial

Editorial: Tubulinopathies: fundamental and clinical challenges

Antonella Sferra et al. Front Cell Neurosci. .
No abstract available

Keywords: KIF21A; TUBA1A; TUBB3; neurodegeneration; neurodevelopment; tubulin (microtubules); tubulinopathies.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Microtubule comlexity and microtubule related diseases. (A, B) Microtubule complexity is generated by the expression of different α and β-tubulin isotypes and by the addition of post translational modifications, which have the potential to tune microtubule dynamics, stability and interactions with MAPS. (C) Mutations in tubulin genes cause a class of neurological diseases known as tubulinopathies, which include both malformations of the central nervous system and neurodegenerative disorders. (D) Microtubule alteration are also considered a pathomechanism underlying neuron dysfunction in a wide range of neurodegenerative diseases. (C, D) Thus, microtubule- based therapies represent a promising strategy to prevent or rescue microtubule dysfunction occurring in neurological disorders. The figure has been created in “BioRender.com”.
See this image and copyright information in PMC

Comment on

  • Editorial on the Research Topic Tubulinopathies: fundamental and clinical challenges

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