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Review
. 2023 Oct 18;9(10):e21168.
doi: 10.1016/j.heliyon.2023.e21168. eCollection 2023 Oct.

Association between psoriasis and serum apolipoprotein A1 and B: A systematic review and meta-analysis

Fang Wang  1 , Yuan Wang  2 , Xiangyi Kong  1 , Jing Mu  1 , Zhimin Wang  1 , Xuesong Yang  3 , Jianzhou Ye  3
Affiliations
Review

Association between psoriasis and serum apolipoprotein A1 and B: A systematic review and meta-analysis

Fang Wang et al. Heliyon. .

Abstract

Background: Psoriasis has been linked to dyslipidemia. However, the magnitude of the association between psoriasis and serum apolipoproteins A1 and B remains unclear.

Methods: We systematically searched PubMed, Embase, and Cochrane Library databases for eligible studies published before August 10, 2023. Data were pooled using Stata software. We adopted a random-effects model for the meta-analysis. Additionally, we conducted subgroup analyses of the studies according to the psoriasis type and matched body mass index (BMI).

Results: Seventeen studies involving 2467 participants were included. Psoriasis was associated with decreased serum apolipoprotein A1 (weighted mean difference [WMD] = -9.05, P < 0.001) and increased serum apolipoprotein B (WMD = 11.68, P < 0.001). In subgroup analysis after matching BMI, the findings showing an association of psoriasis with serum apolipoprotein A1 (WMD = -14.07, P < 0.001) and serum apolipoprotein B (WMD = 13.07, P < 0.001) were consistent with the overall results. The subgroup analysis for the presence or absence of psoriatic arthritis showed that serum apolipoprotein A1 was significantly decreased in psoriasis with (WMD = -11.29, P < 0.001) and without arthritis (WMD = -8.69, P = 0.039); whereas serum apolipoprotein B was significantly increased in psoriasis with (WMD = 13.57, P < 0.001) and without arthritis (WMD = 9.21, P < 0.001).

Conclusions: Our study revealed that psoriasis is associated with decreased serum apolipoprotein A1 and increased serum apolipoprotein B levels compared with healthy controls.

Keywords: Apolipoprotein A1; Apolipoprotein B; Lipid metabolism; Meta-analysis; Psoriasis.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flow diagram for the study selection process.
Fig. 2
Fig. 2
Forest plot for meta-analysis on the association between psoriasis and serum apolipoprotein A1 (weighted mean difference). CI: confidence interval; I2: inconsistency.
Fig. 3
Fig. 3
Sensitivity analysis of the association between psoriasis and serum apolipoprotein A1. CI: confidence interval.
Fig. 4
Fig. 4
Forest plot for meta-analysis on the association between psoriasis and serum apolipoprotein B (weighted mean difference). CI: confidence interval; I2: inconsistency.
Fig. 5
Fig. 5
Sensitivity analysis of the association between psoriasis and serum apolipoprotein B. CI: confidence interval.
See this image and copyright information in PMC

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