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. 1986;224(6):520-4.
doi: 10.1007/BF02154739.

The effect of topical cyclosporin A on the rabbit cornea. A clinical and electron microscopic study

W Behrens-Baumann, S Theuring, H Brewitt

The effect of topical cyclosporin A on the rabbit cornea. A clinical and electron microscopic study

W Behrens-Baumann et al. Graefes Arch Clin Exp Ophthalmol. 1986.

Abstract

To investigate the effect of topical cyclosporin A (CSA) on the rabbit cornea, both eyes of 80 animals were treated with CSA 2% eye drops over a 3-week period under various conditions. CSA was dissolved in castor oil or ethanol 13.8 vol. %. Slit-lamp, scanning and transmission electron microscopic examinations were performed. CSA 2% in castor oil given 5 times daily showed no damage to either the corneal epithelium or endothelium. In contrast the solutions containing ethanol revealed considerable epithelial cell damage.

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