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Review
. 2023 Oct 16;20(13):1722-1731.
doi: 10.7150/ijms.86832. eCollection 2023.

Extracellular Vesicles in Sepsis: Pathogenic Roles, Organ Damage, and Therapeutic Implications

Ni An  1 , Zhe Chen  2 , Peng Zhao  1 , Wen Yin  1
Affiliations
Review

Extracellular Vesicles in Sepsis: Pathogenic Roles, Organ Damage, and Therapeutic Implications

Ni An et al. Int J Med Sci. .

Abstract

Despite significant advances in anti-infective treatment and organ function support technology in recent years, the mortality rate of sepsis remains high. In addition to the high costs of sepsis treatment, the increasing consumption of medical resources also aggravates economic pressure and social burden. Extracellular vesicles (EVs) are membrane vesicles released from different types of activated or apoptotic cells to mediate intercellular communication, which can be detected in both human and animal body fluids. A growing body of researches suggest that EVs play an important role in the pathogenesis of sepsis. In this review, we summarize the predominant roles of EVs in various pathological processes during sepsis and its related organ dysfunction.

Keywords: exosomes; extracellular vesicles; inflammation; organ dysfunction; sepsis.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Role of EVs in sepsis.
See this image and copyright information in PMC

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