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Review
. 2023 Nov 2;8(4):24730114231207643.
doi: 10.1177/24730114231207643. eCollection 2023 Oct.

Contemporary Review: The Use of Adipocyte-Derived Mesenchymal Stem Cells in Pathologies of the Foot and Ankle

Albert T Anastasio  1 , Kian Bagheri  1   2 , Samuel B Adams  1
Affiliations
Review

Contemporary Review: The Use of Adipocyte-Derived Mesenchymal Stem Cells in Pathologies of the Foot and Ankle

Albert T Anastasio et al. Foot Ankle Orthop. .
No abstract available

Keywords: Achilles tendinopathy; adipose tissue; adipose-derived mesenchymal stem cells; ankle osteoarthritis; hallux rigidus; liposuction; osteochondral lesions of the talus; outcome studies; plantar fasciitis.

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Conflict of interest statement

The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Samuel B. Adams, MD, reports consulting fees from Regeneration Technologies, Inc. ICMJE forms for all authors are available online.

Figures

Figure 1.
Figure 1.
Areas of the body with a high concentration of brown adipose tissue (circled in brown) and a high concentration of white adipose tissue (circled in white).
Figure 2.
Figure 2.
The processing methodology for adipose-derived mesenchymal stem cells. This process is not FDA-approved.
Figure 3.
Figure 3.
Mechanism of the FDA-approved Lipogems® device. This process involves the original adipose tissue being pushed through the blue filter for the first cluster reduction. The core device is then aggressively shaken several times until the saline solution washes off the residual blood and oil. The second cluster reduction is then performed to obtain micro-fragmented adipose tissue via the extrusion of the inner adipose clusters into a syringe. Image courtesy of Xu et al. Abbreviations: FDA, Food and Drug Administration; MFAT, micro-fragmented adipose tissue.
See this image and copyright information in PMC

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