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Comparative Study
. 1986 Sep;88(3):189-94.
doi: 10.1254/fpj.88.189.

[Inhibition of the slow-reacting substance of anaphylaxis generation by ubiquinone derivatives]

[Article in Japanese]
Y Ashida, K Okamoto, Y Maki
Comparative Study

[Inhibition of the slow-reacting substance of anaphylaxis generation by ubiquinone derivatives]

[Article in Japanese]
Y Ashida et al. Nihon Yakurigaku Zasshi. 1986 Sep.

Abstract

The slow-reacting substance of anaphylaxis (SRS-A) is generated in lung fragments of the actively sensitized guinea pig by an antigen-antibody reaction. The SRS-A generation in lung fragments was inhibited by its quinonyl acid (QS), and quinonyl-alcohol (QSA) derivatives of ubiquinone from a concentration as low as 10(-7) M. It was of interest that the C10 and C13 side chain length in the 6-position of ubiquinone provided the highest activity. These compounds showed no antagonistic activity towards the contractile response of guinea pig ileum to SRS-A, indicating that the compounds inhibit the biosynthesis of SRS-A.

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