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. 2023 Oct 31;7(6):pkad073.
doi: 10.1093/jncics/pkad073.

Systematic symptom management in the IMPACT Consortium: rationale and design for 3 effectiveness-implementation trials

Ashley Wilder Smith  1 , Lisa DiMartino  2   3 , Sofia F Garcia  4 , Sandra A Mitchell  1 , Kathryn J Ruddy  5 , Justin D Smith  6 , Sandra L Wong  7 , September Cahue  8 , David Cella  4 , Roxanne E Jensen  1 , Michael J Hassett  9 , Christine Hodgdon  10 , Barbara Kroner  3 , Raymond U Osarogiagbon  11 , Jennifer Popovic  12 , Kimberly Richardson  13 , Deborah Schrag  14 , Andrea L Cheville  15 ; IMPACT Consortium
Collaborators, Affiliations

Systematic symptom management in the IMPACT Consortium: rationale and design for 3 effectiveness-implementation trials

Ashley Wilder Smith et al. JNCI Cancer Spectr. .

Abstract

Cancer and its treatment produce deleterious symptoms across the phases of care. Poorly controlled symptoms negatively affect quality of life and result in increased health-care needs and hospitalization. The Improving the Management of symPtoms during And following Cancer Treatment (IMPACT) Consortium was created to develop 3 large-scale, systematic symptom management systems, deployed through electronic health record platforms, and to test them in pragmatic, randomized, hybrid effectiveness and implementation trials. Here, we describe the IMPACT Consortium's conceptual framework, its organizational components, and plans for evaluation. The study designs and lessons learned are highlighted in the context of disruptions related to the COVID-19 pandemic.

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Conflict of interest statement

The authors have nothing to disclose.

Figures

Figure 1.
Figure 1.
IMPACT conceptual framework. IMPACT = Improving the Management of symPtoms during And following Cancer Treatment.
Figure 2.
Figure 2.
IMPACT Consortium conceptual framework. E2C2 = EHR-facilitated cancer symptom control; EHR = electronic health record; IMPACT = Improving the Management of symPtoms during And following Cancer Treatment; NU IMPACT = Northwestern University IMPACT; SIMPRO = Symptom Management IMplementation of Patient Reported Outcomes in Oncology.
See this image and copyright information in PMC

References

    1. Xu H, Mohamed M, Flannery M, et al. An unsupervised machine learning approach to evaluating the association of symptom clusters with adverse outcomes among older adults with advanced cancer: a secondary analysis of a randomized clinical trial. JAMA Netw Open. 2023;6(3):e234198. - PMC - PubMed
    1. Badger TA, Segrin C, Crane TE, et al. Social determinants of health and symptom burden during cancer treatment. Nurs Res. 2023;72(2):103-113. - PMC - PubMed
    1. Sikorskii A, Given CW, Chang S, et al. Patient reported outcomes and unscheduled health services use during oral anti-cancer treatment. J Pain Symptom Manage. 2023;65(2):e115-e121. - PMC - PubMed
    1. Batra A, Yang L, Boyne DJ, et al. Associations between baseline symptom burden as assessed by patient-reported outcomes and overall survival of patients with metastatic cancer. Support Care Cancer. 2021;29(3):1423-1431. - PubMed
    1. Cho B, Pérez M, Jeffe DB, et al. Factors associated with initiation and continuation of endocrine therapy in women with hormone receptor-positive breast cancer. BMC Cancer. 2022;22(1):837. - PMC - PubMed

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