Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 6;109(6):1213-1219.
doi: 10.4269/ajtmh.23-0437. Print 2023 Dec 6.

β-Blockers in Hepatosplenic Schistosomiasis: A Narrative Review

Fernanda Alves Gelape  1 , Claudia Alves Couto  2 , Guilherme Grossi Lopes Cançado  2   3
Affiliations
Review

β-Blockers in Hepatosplenic Schistosomiasis: A Narrative Review

Fernanda Alves Gelape et al. Am J Trop Med Hyg. .

Abstract

Hepatosplenic schistosomiasis (HSS) is a serious complication of chronic schistosomiasis that can result in portal hypertension and variceal bleeding. β-blockers, a class of medications commonly used to treat hypertension and other cardiovascular conditions, have been investigated for their potential use in preventing variceal bleeding in HSS. Several studies have shown that β-blockers can reduce portal pressure and prevent variceal bleeding effectively in these patients. However, there are limited data on the long-term efficacy and safety of β-blockers in this setting, and further research is needed to determine the optimal use of these medications. This review summarizes the evidence supporting current recommendations of β-blocker use in patients with HSS.

PubMed Disclaimer

References

    1. World Health Organization , 2021. Ending the Neglect to Attain the Sustainable Development Goals: A Road Map for Neglected Tropical Diseases 2021–2030. Available at: https://www.who.int/publications/i/item/9789240010352. Accessed May 12, 2023.
    1. World Health Organization , 2013. Schistosomiasis: Progress Report 2001–2011, Strategic Plan 2012–2020. Available at: https://apps.who.int/iris/handle/10665/78074. Accessed May 12, 2023.
    1. Institute for Health Metrics and Evaluation , 2019. Schistosomiasis: Level 3 Cause. Available at: https://www.healthdata.org/results/gbd_summaries/2019/schistosomiasis-le.... Accessed March 31, 2023.
    1. Montresor A, Mwinzi P, Mupfasoni D, Garba A, 2022. Reduction in DALYs lost due to soil-transmitted helminthiases and schistosomiasis from 2000 to 2019 is parallel to the increase in coverage of the global control programmes. PLoS Negl Trop Dis 16: e0010575. - PMC - PubMed
    1. Gunda DW, Kilonzo SB, Manyiri PM, Peck RN, Mazigo HD, 2020. Morbidity and mortality due to Schistosoma mansoni related periportal fibrosis: could early diagnosis of varices improve the outcome following available treatment modalities in sub Saharan Africa? A scoping review. Trop Med Infect Dis 5: 20. - PMC - PubMed

MeSH terms

LinkOut - more resources