The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Candice Roufosse¹, Maarten Naesens², Mark Haas³, Carmen Lefaucheur⁴, Roslyn B Mannon⁵, Marjan Afrouzian⁶, Nada Alachkar⁷, Olivier Aubert⁸, Serena M Bagnasco⁹, Ibrahim Batal¹⁰, Chris O C Bellamy¹¹, Verena Broecker¹², Klemens Budde¹³, Marian Clahsen-Van Groningen¹⁴, Shana M Coley¹⁵, Lynn D Cornell¹⁶, Darshana Dadhania¹⁷, Anthony J Demetris¹⁸, Gunilla Einecke¹⁹, Alton B Farris²⁰, Agnes B Fogo²¹, John Friedewald²², Ian W Gibson²³, Catherine Horsfield²⁴, Edmund Huang²⁵, Syed A Husain²⁶, Annette M Jackson²⁷, Jesper Kers²⁸, Željko Kikić²⁹, Amanda Klein³⁰, Nicolas Kozakowski³¹, Helen Liapis³², Massima Mangiola³³, Robert A Montgomery³⁴, Brian Nankinvell³⁵, Desley A H Neil³⁶, Peter Nickerson³⁷, Marion Rabant³⁸, Parmjeet Randhawa³⁹, Leonardo V Riella⁴⁰, Ivy Rosales⁴¹, Virginie Royal⁴², Ruth Sapir-Pichhadze⁴³, Pinaki Sarder⁴⁴, Minnie Sarwal⁴⁵, Carrie Schinstock⁴⁶, Mark Stegall⁴⁷, Kim Solez⁴⁸, Jeroen van der Laak⁴⁹, Chris Wiebe³⁷, Robert B Colvin⁵⁰, Alexandre Loupy⁸, Michael Mengel⁴⁸

Affiliations

¹ Department of Immunology and Inflammation, Faculty Medicine, Imperial College London, London, UK. Electronic address: c.roufosse@imperial.ac.uk.
² Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. Electronic address: maarten.naesens@kuleuven.be.
³ Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
⁴ Université Paris Cité, INSERM, PARCC, Paris Institute for Transplantation and Organ Regeneration, France & Department of Nephrology and Transplantation, Saint-Louis Hospital, Paris, France.
⁵ Department of Internal Medicine, Division of Nephrology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
⁶ Department of Pathology, University of Texas Medical Branch at Galveston, Texas, USA.
⁷ Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁸ Université Paris Cité, INSERM, PARCC, Paris Institute for Transplantation and Organ Regeneration, France & Department of Transplantation, Necker Hospital, Paris, France.
⁹ Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
¹⁰ Pathology & Cell Biology, Columbia University Irving Medical Center, New York, USA.
¹¹ Division of Pathology, University of Edinburgh, Scotland.
¹² Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
¹³ Department of Nephrology, Charité Universitätsmedizin, Berlin, Germany.
¹⁴ Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
¹⁵ Transplant Translational Research, Arkana Laboratories, Arkansas, USA.
¹⁶ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁷ Department Medicine, Weill Cornell Medical College of Cornell University, New York, New York, USA.
¹⁸ UPMC Hepatic and Transplantation Pathology, Pittsburg, Pennsylvania, USA.
¹⁹ Department of Nephrology and Rheumatology, University Medical Center Göttingen, Germany.
²⁰ Department of Pathology and Laboratory Medicine, Emory University, USA.
²¹ Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
²² Comprehensive Transplant Center, Northwestern University, USA.
²³ Department of Pathology, University of Manitoba, Winnipeg, Canada.
²⁴ Dept of Histopathology, Guy's & St Thomas' Hospital, London, UK.
²⁵ Department of Medicine, Division of Nephrology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
²⁶ Division of Nephrology, Columbia University, New York, New York, USA.
²⁷ Department of Surgery, Duke University, Durham, North Carolina, USA.
²⁸ Department of Pathology, Leiden University Medical Center, Netherlands; Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
²⁹ Department of Urology, Medical University of Vienna, Vienna, Austria.
³⁰ Critical Path Institute, Tucson, Arizona, USA.
³¹ Department of Pathology, Medical University of Vienna, Vienna, Austria.
³² Ludwig Maximillian University Munich, Nephrology Center, Germany.
³³ Transplant Institute, NYU Langone Health, New York, USA.
³⁴ NYU Langone Transplant Institute, New York, USA.
³⁵ Department of Renal Medicine, Westmead Hospital, Westmead, New South Wales, Australia.
³⁶ Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham and Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
³⁷ Department of Medicine and Department of Immunology, University of Manitoba, Winnipeg, Canada.
³⁸ Pathology department, Necker-Enfants Malades Hospital, Paris, France.
³⁹ Pathology, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
⁴⁰ Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
⁴¹ Immunopathology Research Laboratory, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁴² Maisonneuve-Rosemont Hospital, University of Montreal, Quebec, Canada.
⁴³ Division of Nephrology & Multiorgan Transplant Program, McGill University, Montreal, Quebec, Canada.
⁴⁴ Department of Medicine-Quantitative Health, University of Florida College of Medicine, Florida, USA.
⁴⁵ Division of MultiOrgan Transplantation, UCSF, San Francisco, California, USA.
⁴⁶ Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
⁴⁷ Department Transplantation Surgery, Mayo Clinic, Rochester, Massachusetts, USA.
⁴⁸ Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
⁴⁹ Department of Pathology, Radboud University Medical Center, Netherlands.
⁵⁰ Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

PMID: 37931753
PMCID: PMC11135910
DOI: 10.1016/j.ajt.2023.10.031

The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Candice Roufosse et al. Am J Transplant. 2024 Mar.

. 2024 Mar;24(3):350-361.

doi: 10.1016/j.ajt.2023.10.031. Epub 2023 Nov 4.

Authors

Affiliations

¹ Department of Immunology and Inflammation, Faculty Medicine, Imperial College London, London, UK. Electronic address: c.roufosse@imperial.ac.uk.
² Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. Electronic address: maarten.naesens@kuleuven.be.
³ Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
⁴ Université Paris Cité, INSERM, PARCC, Paris Institute for Transplantation and Organ Regeneration, France & Department of Nephrology and Transplantation, Saint-Louis Hospital, Paris, France.
⁵ Department of Internal Medicine, Division of Nephrology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
⁶ Department of Pathology, University of Texas Medical Branch at Galveston, Texas, USA.
⁷ Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁸ Université Paris Cité, INSERM, PARCC, Paris Institute for Transplantation and Organ Regeneration, France & Department of Transplantation, Necker Hospital, Paris, France.
⁹ Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
¹⁰ Pathology & Cell Biology, Columbia University Irving Medical Center, New York, USA.
¹¹ Division of Pathology, University of Edinburgh, Scotland.
¹² Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
¹³ Department of Nephrology, Charité Universitätsmedizin, Berlin, Germany.
¹⁴ Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
¹⁵ Transplant Translational Research, Arkana Laboratories, Arkansas, USA.
¹⁶ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁷ Department Medicine, Weill Cornell Medical College of Cornell University, New York, New York, USA.
¹⁸ UPMC Hepatic and Transplantation Pathology, Pittsburg, Pennsylvania, USA.
¹⁹ Department of Nephrology and Rheumatology, University Medical Center Göttingen, Germany.
²⁰ Department of Pathology and Laboratory Medicine, Emory University, USA.
²¹ Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
²² Comprehensive Transplant Center, Northwestern University, USA.
²³ Department of Pathology, University of Manitoba, Winnipeg, Canada.
²⁴ Dept of Histopathology, Guy's & St Thomas' Hospital, London, UK.
²⁵ Department of Medicine, Division of Nephrology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
²⁶ Division of Nephrology, Columbia University, New York, New York, USA.
²⁷ Department of Surgery, Duke University, Durham, North Carolina, USA.
²⁸ Department of Pathology, Leiden University Medical Center, Netherlands; Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
²⁹ Department of Urology, Medical University of Vienna, Vienna, Austria.
³⁰ Critical Path Institute, Tucson, Arizona, USA.
³¹ Department of Pathology, Medical University of Vienna, Vienna, Austria.
³² Ludwig Maximillian University Munich, Nephrology Center, Germany.
³³ Transplant Institute, NYU Langone Health, New York, USA.
³⁴ NYU Langone Transplant Institute, New York, USA.
³⁵ Department of Renal Medicine, Westmead Hospital, Westmead, New South Wales, Australia.
³⁶ Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham and Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
³⁷ Department of Medicine and Department of Immunology, University of Manitoba, Winnipeg, Canada.
³⁸ Pathology department, Necker-Enfants Malades Hospital, Paris, France.
³⁹ Pathology, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
⁴⁰ Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
⁴¹ Immunopathology Research Laboratory, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁴² Maisonneuve-Rosemont Hospital, University of Montreal, Quebec, Canada.
⁴³ Division of Nephrology & Multiorgan Transplant Program, McGill University, Montreal, Quebec, Canada.
⁴⁴ Department of Medicine-Quantitative Health, University of Florida College of Medicine, Florida, USA.
⁴⁵ Division of MultiOrgan Transplantation, UCSF, San Francisco, California, USA.
⁴⁶ Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
⁴⁷ Department Transplantation Surgery, Mayo Clinic, Rochester, Massachusetts, USA.
⁴⁸ Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
⁴⁹ Department of Pathology, Radboud University Medical Center, Netherlands.
⁵⁰ Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

PMID: 37931753
PMCID: PMC11135910
DOI: 10.1016/j.ajt.2023.10.031

Abstract

The XVIth Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from September 19 to 23, 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular inflammation and biopsy-based transcript analysis on the Banff Classification, further sessions were devoted to other aspects of kidney transplant pathology, in particular T cell-mediated rejection, activity and chronicity indices, digital pathology, xenotransplantation, clinical trials, and surrogate endpoints. Although the output of these sessions has not led to any changes in the classification, the key role of Banff Working Groups in phrasing unanswered questions, and coordinating and disseminating results of investigations addressing these unanswered questions was emphasized. This paper summarizes the key Banff Meeting 2022 sessions not covered in the Banff Kidney Meeting 2022 Report paper and also provides an update on other Banff Working Group activities relevant to kidney allografts.

Keywords: Banff; allograft; classification; pathology; work plan; working groups.

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Conflict of interest statement

Declaration of competing interest

The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation.

References

1. Naesens M, Roufosse C, Colvin RB, et al. The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostic. Am J Transplant. 2024;24:338–349. - PubMed
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The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Affiliations

The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Authors

Affiliations

Abstract

Conflict of interest statement

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical