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Review
. 2024 Jan 2;19(1):e202300815.
doi: 10.1002/asia.202300815. Epub 2023 Nov 6.

Transition-Metal-Catalyzed Directed C-H Functionalization in/on Water

Tariq A Shah  1 , Tanumay Sarkar  2 , Subhradeep Kar  2 , Prabhat Kumar Maharana  2 , Kangkan Talukdar  2 , Tharmalingam Punniyamurthy  2
Affiliations
Review

Transition-Metal-Catalyzed Directed C-H Functionalization in/on Water

Tariq A Shah et al. Chem Asian J. .

Abstract

Directing group assisted C-H bond functionalization using transition-metal-catalysis has emerged as a reliable synthetic tool for the construction of regioselective carbon-carbon/heteroatom bonds. Off late, "in/on water directed transition-metal-catalysis", though still underdeveloped, has appeared as one of the prominent themes in sustainable organic chemistry. This article covers the advancements, mechanistic insights and application of the sustainable directed C-H bond functionalization of (hetero)arenes in/on water in the presence of transition-metal-catalysis.

Keywords: Directing group; Site-selective C−H Functionalization; reaction in/on water; transition-metal-catalysis.

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