Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2023 Nov 7;18(11):e0293502.
doi: 10.1371/journal.pone.0293502. eCollection 2023.

The effect of mindfulness on decision-making, inhibitory control, and impulsivity of substance use disorder in-treatment patients: A randomized clinical trial

Ana Paula Gonçalves Donate  1 , Elizeu Coutinho de Macedo  2 , André Bedendo  1 , Itamar Félix Júnior  1 , Giovanna Gonçalves Gallo  1 , Emérita Sátiro Opaleye  1 , Ana Regina Noto  1
Affiliations
Randomized Controlled Trial

The effect of mindfulness on decision-making, inhibitory control, and impulsivity of substance use disorder in-treatment patients: A randomized clinical trial

Ana Paula Gonçalves Donate et al. PLoS One. .

Abstract

This study aimed to investigate the effects of Mindfulness-Based Relapse Prevention (MBRP) in decision-making, inhibitory control and impulsivity compared to Treatment as Usual (TAU) for individuals with Substance Use Disorders (SUD's) in Brazil. A randomized clinical trial was conducted with participants from a therapeutic community (n = 122). Decision-making (Iowa Gambling Task), impulsivity dimensions (UPPS-P Scale), and inhibitory control (Stroop Color-Word Test) were assessed before and after the MBRP 8-week intervention. GLM Multivariate analysis was used to evaluate the effects of MBRP on different impulsivity measures. The results showed that MBRP+TAU improved the general decision-making score (p = 0,008) compared to TAU. However, no significant effects were found in impulsivity dimensions and inhibitory control in individuals with SUDs in the therapeutic community. This study found improvement in decision-making in the total IGT score; however, no effect for self-reported impulsivity and inhibitory control among middle-aged patients after an 8-weeks intervention of MBRP protocol in an inpatient setting. It adds information to the subject, with implications and possible directions to be followed by the next clinical trials with patients with SUDs in treatment. Trial registration: EnsaiosClinicos.gov.br: RBR-6c9njc.

PubMed Disclaimer

Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: ARN is the director of the Brazilian center that conducts MBRP training with financial incentives. ESO was an MBRP teacher in this center until 2019. Other authors have declared that no competing interests exist. This does not alter out adherence to PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. SPIRIT schedule presenting participant timeline.
Fig 2
Fig 2. CONSORT flow diagram.
Fig 3
Fig 3. Fluxogram of the experimental design.
See this image and copyright information in PMC

References

    1. UNODC. Drug Use and Health Consequences. In: World Drug Report 2020. 2020. p. 1–52.
    1. Bastos FI. III Levantamento Nacional sobre o uso de drogas pela população brasileira. 2017.
    1. Félix-Junior I, Donate AP, Noto AR, Galduróz JC, Simionato NM, Opaleye ES. Mindfulness-based Interventions in inpatient treatment for SUDs: a systematic review. Addictive Behaviors Reports. 2022;16(September):100467. - PMC - PubMed
    1. Evren C, Durkaya M, Evren B, Dalbudak E, Cetin R. Relationship of relapse with impulsivity, novelty seeking and craving in male alcohol-dependent inpatients. Drug Alcohol Rev. 2012;31(1). doi: 10.1111/j.1465-3362.2011.00303.x - DOI - PubMed
    1. Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. American Journal of Psychiatry. 2001;158(11):1783–93. doi: 10.1176/appi.ajp.158.11.1783 - DOI - PubMed

Publication types