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. 2023 Sep 18;4(10):662-667.
doi: 10.1016/j.hroo.2023.09.005. eCollection 2023 Oct.

Comprehensive dose-response study of pulsed field ablation using a circular catheter compared with radiofrequency ablation for pulmonary vein isolation: A preclinical study

Jonathan C Hsu  1 , Rajesh S Banker  2 , Douglas N Gibson  3 , Tara Gomez  4 , Dror Berman  4 , Keshava Datta  4 , Qi Chen  4 , Shephal K Doshi  5
Affiliations

Comprehensive dose-response study of pulsed field ablation using a circular catheter compared with radiofrequency ablation for pulmonary vein isolation: A preclinical study

Jonathan C Hsu et al. Heart Rhythm O2. .
No abstract available

Keywords: Catheter ablation; Irreversible electroporation; Preclinical model; Pulmonary vein isolation; Pulsed field ablation.

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Figures

None
Graphical abstract
Figure 1
Figure 1
Voltage maps by study arm. Voltage maps and electrogram readouts preablation, postablation (acute), and after day 30 ± 5 (chronic). In ablation location images, purple tags indicate pulsed field ablation ablations and red tags indicate radiofrequency (RF) ablations. Voltage is represented on a color scale from purple (high voltage, healthy tissue) to red (low voltage, scar tissue).
Figure 2
Figure 2
Summary of dose response. ∗N = 6 veins per group. †N = 3 animals per group. ‡Esophageal injury, phrenic nerve injury, and injury to upstream and downstream tissues. LA = left atrium; PFA = pulsed-field ablation; PV = pulmonary vein; PW = posterior wall; RF = radiofrequency.
Figure 3
Figure 3
Histopathologic findings with pulsed field ablation (PFA) vs radiofrequency (RF) ablation.
Figure 4
Figure 4
Histopathologic observations demonstrating large amounts of severe chronic inflammation in radiofrequency (RF)-treated tissue (based on average histopathologic score) in comparison to pulsed field ablation (PFA)–treated tissue with no or minimal inflammation. PMN = polymorphonuclear neutrophil.
See this image and copyright information in PMC

References

    1. Rubinsky B., Onik G., Mikus P. Irreversible electroporation: a new ablation modality—clinical implications. Technol Cancer Res Treat. 2007;6:37–48. - PubMed
    1. Moshkovits Y., Grynberg D., Heller E., Maizels L., Maor E. Differential effect of high-frequency electroporation on myocardium vs. non-myocardial tissues. Europace. 2023;25:748–755. - PMC - PubMed
    1. Yavin H., Brem E., Zilberman I., et al. A circular multielectrode pulsed-field ablation catheter "Lasso PFA": lesion characteristics, durability and effect on neighboring structures. Circ Arrhythm Electrophysiol. 2021;14 - PMC - PubMed
    1. Grimaldi M., Di Monaco A., Gomez T., et al. Time course of irreversible electroporation lesion development through short- and long-term follow-up in pulsed-field ablation-treated hearts. Circ Arrhythm Electrophysiol. 2022;15 - PubMed
    1. Hsu J.C., Gibson D., Banker R., et al. In vivo porcine characterization of atrial lesion safety and efficacy utilizing a circular pulsed-field ablation catheter including assessment of collateral damage to adjacent tissue in supratherapeutic ablation applications. J Cardiovasc Electrophysiol. 2022;33:1480–1488. - PMC - PubMed

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