Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025;19(1):4-16.
doi: 10.2174/0118722105253055231016155618.

Diabetology and Nanotechnology: A Compelling Combination

Affiliations
Review

Diabetology and Nanotechnology: A Compelling Combination

Ritu Karwasra et al. Recent Pat Nanotechnol. 2025.

Abstract

The convergence of diabetology and nanotechnology has emerged as a promising synergy with the potential to revolutionize the management and treatment of diabetes mellitus. Diabetes, a complex metabolic disorder affecting millions worldwide, necessitates innovative approaches to enhance monitoring, diagnosis, and therapeutic interventions. Nanotechnology, a burgeoning field that manipulates materials at the nanoscale, offers unprecedented opportunities to address the challenges posed by diabetes. This abstract explores the multifaceted interface between diabetology and nanotechnology, highlighting key areas of integration. Nanotechnology has paved the way for the development of advanced glucose monitoring systems with enhanced accuracy, sensitivity, and patient convenience. Miniaturized biosensors and implantable devices equipped with nanoscale materials enable continuous and real-time glucose monitoring, empowering individuals with diabetes to make timely and informed decisions about their dietary and insulin management. Furthermore, nanotechnology has facilitated breakthroughs in targeted drug delivery, addressing the limitations of conventional therapies in diabetes treatment. Nano-sized drug carriers can improve bioavailability, enable controlled release, and enhance the selectivity of therapeutic agents, minimizing side effects and optimizing treatment outcomes. Moreover, nanoengineered materials have opened avenues for tissue engineering and regenerative medicine, offering the potential to restore damaged pancreatic islets and insulin-producing cells. The amalgamation of diabetology and nanotechnology also holds promise for early disease detection and prevention. Nanoscale diagnostic tools, such as biomarker-based nanoprobes and lab-onchip devices, offer rapid and accurate detection of diabetes-related biomolecules, enabling timely interventions and reducing the risk of complications. However, this compelling combination also presents challenges that warrant careful consideration. Safety, biocompatibility, regulatory approval, and ethical implications are crucial factors that demand meticulous evaluation during the translation of nanotechnology-based solutions into clinical practice. In conclusion, the integration of diabetology and nanotechnology represents a transformative paradigm that has the potential to reshape the landscape of diabetes management. By harnessing the unique properties of nanoscale materials, researchers and clinicians are poised to usher in an era of personalized and precise diagnostics, therapeutics, and preventive strategies for diabetes mellitus. As advancements in nanotechnology continue to unfold, the journey towards realizing the full potential of this compelling combination remains an exciting frontier in medical science. This review has thoroughly and critically studied the usage of nanomedicine in the diagnosis, monitoring, and management of diabetes and its effects, providing a clear picture of their potential clinical application in the future. This evaluation covers additional numerous clinical trials research and patents that are currently in way in this subject. Thus in the light of this we intended to provide a broad picture of the state of technological development in the area of diabetes management through nanotechnology.

Keywords: Nanotechnology; anti-diabetic drug delivery; diabetes mellitus; diagnosis; nanoparticles; nanoscale diagnostic tools..

PubMed Disclaimer

References

    1. He Y.; Al-Mureish A.; Wu N.; Nanotechnology in the treatment of diabetic complications: A comprehensive narrative review. J Diabetes Res 2021,2021,1-11 - DOI - PubMed
    1. Sharma R.; Borah S.J.; Kumar S.; Emerging trends in nano-based antidiabetic therapeutics: A path to effective diabetes management. Mater Adv 2023,4(15),3091-3113 - DOI
    1. Liu M.; Wei X.; Zheng Z.; Recent advances in nano-drug delivery systems for the treatment of diabetic wound healing. Int J Nanomedicine 2023,18,1537-1560 - DOI - PubMed
    1. Patra P.; Choudhury S.; Recent developments in nano-formulations against diabetes. Recent Pat Nanotechnol 2023,17(4),340-358 - DOI - PubMed
    1. Turner R.; Holman R.; Matthews D.; UK prospective diabetes study (UKPDS). Diabetologia 1991,34(12),877-890 - DOI - PubMed