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Review
. 2024;24(4):381-393.
doi: 10.2174/0118715303250271231018103202.

Mitochondrial Inherited Disorders and their Correlation with Neurodegenerative Diseases

Sofjana Gushi  1 , Vasileios Balis  1
Affiliations
Review

Mitochondrial Inherited Disorders and their Correlation with Neurodegenerative Diseases

Sofjana Gushi et al. Endocr Metab Immune Disord Drug Targets. 2024.

Abstract

Mitochondria are essential organelles for the survival of a cell because they produce energy. The cells that need more mitochondria are neurons because they perform a variety of tasks that are necessary to support brain homeostasis. The build-up of abnormal proteins in neurons, as well as their interactions with mitochondrial proteins, or MAM proteins, cause serious health issues. As a result, mitochondrial functions, such as mitophagy, are impaired, resulting in the disorders described in this review. They are also due to mtDNA mutations, which alter the heritability of diseases. The topic of disease prevention, as well as the diagnosis, requires further explanation and exploration. Finally, there are treatments that are quite promising, but more detailed research is needed.

Keywords: Mitochondria; heritability; homeostasis.; mitochondrial DNA; mitophagy; neurodegeneration.

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References

    1. Chen J.Q.; Yager J.D.; Russo J.; Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications. Biochim Biophys Acta Mol Cell Res 2005,1746(1),1-17 - DOI - PubMed
    1. Science in the news. Mighty mitochondria and neurodegenerative diseases. 2012. Available From: https://sitn.hms.harvard.edu/flash/2012/issue111/
    1. Allen, A. Who discovered mitochondria - who discovered it? 2021. Available From:
    1. MicroscopeMaster. Mitochondria - dfpageinition, discovery, importance and function. 2021. Available From:
    1. NobelPrize. The nobel prize in chemistry 1997 2022. Available From:

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