Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection - 2-Year Outcomes

Brenna L Hughes¹, Rebecca G Clifton², Dwight J Rouse³, George R Saade⁴, Mara J Dinsmoor⁵, Uma M Reddy⁶, Robert Pass⁷, Donna Allard³, Gail Mallett⁵, Cora MacPherson², Ronald Wapner⁸, Torri Metz⁹, William H Goodnight¹⁰, Alan T N Tita⁷, Maged M Costantine¹¹, Geeta K Swamy¹², Kent D Heyborne¹³, Edward K Chien¹⁴, Suneet P Chauhan¹⁵, Yasser Y El-Sayed¹⁶, Brian M Casey¹⁷, Samuel Parry¹⁸, Hyagriv N Simhan¹⁹, Peter G Napolitano²⁰, George A Macones²¹; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network

Collaborators, Affiliations

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network:
B Hughes, D Rouse, D Allard, E Werner, J Rousseau, L Beati, J Milano, J Lee, G Saade, A Salazar, L Pacheco, J Patel, D Carlson, K Smith, A Nounes, J DeVolder, G Mallett, W Grobman, A Peaceman, M Dinsmoor, K Paycheck, C Gyamfi-Bannerman, S Bousleiman, R Wapner, V Carmona, M Talucci, M Hoffman, A Vanneman, K Palomares, C Perez, L Plante, C Tocci, D Skupski, R Chan-Akeley, M Varner, K Hill, A Sowles, C Meadows, S Dellerman, L Hansen, S Esplin, W Goodnight, K Clark, J Thorp, S Timlin, C Beamon, H Byers, K Eichelberger, A Moore, A Tita, S Harris, L Harper, J Biggio, M Parks, J Sheppard, M Costantine, A Bartholomew, M Landon, J Iams, C Shellhaas, K Markham, B Rink, C Buhimschi, F Johnson, L Webb, D McKenna, K Fennig, K Snow, G Swamy, T Bishop, J Ferrara, R Gibbs, K Hale, K D Heyborne, J Phipers, E Chien, W Dalton, D Hackney, A Mayle, S Chauhan, F Ortiz, B Sibai, Y El-Sayed, C Willson, N Aziz, D Lyell, A Girsen, K Sherwi, B Casey, L Moseley, J Price, T Thomas, L Fay-Randall, A Sias, M Garcia, S Parry, J Craig, H Simhan, M Bickus, F Facco, M Birsic, P Napolitano, L Imbruglio, E Hemman, J Pates, L Foglia, E Thom, R Clifton, L Fete, L Mele, V L Flowers-Fanomezantsoa, T Boekhoudt, C MacPherson, U Reddy, C Spong, S Pagliaro

Affiliations

¹ Brown University, Providence, RI brenna.hughes@duke.edu.
² George Washington University, Washington, DC.
³ Brown University, Providence, RI.
⁴ University of Texas Medical Branch, Galveston, TX.
⁵ Northwestern University, Chicago, IL.
⁶ Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
⁷ University of Alabama at Birmingham, Birmingham, AL.
⁸ Columbia University, New York, NY.
⁹ University of Utah Health Sciences Center, Salt Lake City, UT.
¹⁰ University of North Carolina at Chapel Hill, Chapel Hill, NC.
¹¹ Ohio State University, Columbus, OH.
¹² Duke University, Durham, NC.
¹³ University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO.
¹⁴ Case Western Reserve University, Cleveland, OH.
¹⁵ University of Texas Health Science Center at Houston, Houston, TX.
¹⁶ Stanford University, Stanford, CA.
¹⁷ University of Texas Southwestern Medical Center, Dallas, TX.
¹⁸ University of Pennsylvania, Philadelphia, PA.
¹⁹ University of Pittsburgh, Pittsburgh, PA.
²⁰ Madigan Army Medical Center, Joint Base Lewis-McChord, WA.
²¹ Washington University, Saint Louis, MO.

PMID: 37937785
PMCID: PMC10683876
DOI: 10.1056/NEJMc2308286

Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection - 2-Year Outcomes

Brenna L Hughes et al. N Engl J Med. 2023.

. 2023 Nov 9;389(19):1822-1824.

doi: 10.1056/NEJMc2308286.

Authors

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network:
B Hughes, D Rouse, D Allard, E Werner, J Rousseau, L Beati, J Milano, J Lee, G Saade, A Salazar, L Pacheco, J Patel, D Carlson, K Smith, A Nounes, J DeVolder, G Mallett, W Grobman, A Peaceman, M Dinsmoor, K Paycheck, C Gyamfi-Bannerman, S Bousleiman, R Wapner, V Carmona, M Talucci, M Hoffman, A Vanneman, K Palomares, C Perez, L Plante, C Tocci, D Skupski, R Chan-Akeley, M Varner, K Hill, A Sowles, C Meadows, S Dellerman, L Hansen, S Esplin, W Goodnight, K Clark, J Thorp, S Timlin, C Beamon, H Byers, K Eichelberger, A Moore, A Tita, S Harris, L Harper, J Biggio, M Parks, J Sheppard, M Costantine, A Bartholomew, M Landon, J Iams, C Shellhaas, K Markham, B Rink, C Buhimschi, F Johnson, L Webb, D McKenna, K Fennig, K Snow, G Swamy, T Bishop, J Ferrara, R Gibbs, K Hale, K D Heyborne, J Phipers, E Chien, W Dalton, D Hackney, A Mayle, S Chauhan, F Ortiz, B Sibai, Y El-Sayed, C Willson, N Aziz, D Lyell, A Girsen, K Sherwi, B Casey, L Moseley, J Price, T Thomas, L Fay-Randall, A Sias, M Garcia, S Parry, J Craig, H Simhan, M Bickus, F Facco, M Birsic, P Napolitano, L Imbruglio, E Hemman, J Pates, L Foglia, E Thom, R Clifton, L Fete, L Mele, V L Flowers-Fanomezantsoa, T Boekhoudt, C MacPherson, U Reddy, C Spong, S Pagliaro

Affiliations

¹ Brown University, Providence, RI brenna.hughes@duke.edu.
² George Washington University, Washington, DC.
³ Brown University, Providence, RI.
⁴ University of Texas Medical Branch, Galveston, TX.
⁵ Northwestern University, Chicago, IL.
⁶ Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
⁷ University of Alabama at Birmingham, Birmingham, AL.
⁸ Columbia University, New York, NY.
⁹ University of Utah Health Sciences Center, Salt Lake City, UT.
¹⁰ University of North Carolina at Chapel Hill, Chapel Hill, NC.
¹¹ Ohio State University, Columbus, OH.
¹² Duke University, Durham, NC.
¹³ University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO.
¹⁴ Case Western Reserve University, Cleveland, OH.
¹⁵ University of Texas Health Science Center at Houston, Houston, TX.
¹⁶ Stanford University, Stanford, CA.
¹⁷ University of Texas Southwestern Medical Center, Dallas, TX.
¹⁸ University of Pennsylvania, Philadelphia, PA.
¹⁹ University of Pittsburgh, Pittsburgh, PA.
²⁰ Madigan Army Medical Center, Joint Base Lewis-McChord, WA.
²¹ Washington University, Saint Louis, MO.

PMID: 37937785
PMCID: PMC10683876
DOI: 10.1056/NEJMc2308286

No abstract available

PubMed Disclaimer

References

1. Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ, Alford CA. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med 1992;326:663–7. - PubMed
1. Pass RF, Fowler KB, Boppana SB, Britt WJ, Stagno S. Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome. J Clin Virol 2006;35:216–20. - PubMed
1. Stagno S, Pass RF, Dworsky ME, Alford CA Jr. Maternal cytomegalovirus infection and perinatal transmission. Clin Obstet Gynecol 1982;25:563–76. - PubMed
1. Practice bulletin no. 151: cytomegalovirus, parvovirus B19, varicella zoster, and toxoplasmosis in pregnancy. Obstet Gynecol 2015;125:1510–25. - PubMed
1. Hughes BL, Clifton RG, Rouse DJ, et al. A trial of hyperimmune globulin to prevent congenital cytomegalovirus infection. N Engl J Med 2021;385:436–44. - PMC - PubMed

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Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection - 2-Year Outcomes

Collaborators

Affiliations

Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection - 2-Year Outcomes

Authors

Collaborators

Affiliations

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical