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Comment
. 2023 Dec 4;222(12):e202310023.
doi: 10.1083/jcb.202310023. Epub 2023 Nov 8.

BRAG about (s)lots

Joshua C Brown  1   2 , Johannes W Hell  3 , Nashaat Z Gerges  4
Affiliations
Comment

BRAG about (s)lots

Joshua C Brown et al. J Cell Biol. .

Abstract

Mutations in IQSEC2/BRAG1 cause intellectual dysfunction by impairing ARF-GEF activity and long-term depression. In this issue, Bai et al. (https://doi.org/10.1083/jcb.202307117) discover how constitutive ARF-GEF activity is regulated by a closed conformation which opens in the presence of Ca2+. Two known pathogenic mutations cause "leaky" autoinhibition with reduced synaptic dynamic range and impaired cognitive performance.

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References

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