Reply to Gan et al., to Calzetta et al., and to Poor
- PMID: 37939377
- PMCID: PMC10806414
- DOI: 10.1164/rccm.202309-1657LE
Reply to Gan et al., to Calzetta et al., and to Poor
Comment on
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Pharmacological Interpretation of the Efficacy of Ensifentrine in Chronic Obstructive Pulmonary Disease: Insights from ENHANCE Trials.Am J Respir Crit Care Med. 2024 Jan 15;209(2):224-225. doi: 10.1164/rccm.202308-1355LE. Am J Respir Crit Care Med. 2024. PMID: 37939379 Free PMC article. No abstract available.
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Still Thirsty in COPD!Am J Respir Crit Care Med. 2024 Jan 15;209(2):225-226. doi: 10.1164/rccm.202309-1605LE. Am J Respir Crit Care Med. 2024. PMID: 37939380 Free PMC article. No abstract available.
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Inhaled Dual PDE3/4 Inhibitor Ensifentrine for Chronic Obstructive Pulmonary Disease: A Potential Therapeutic Perspective.Am J Respir Crit Care Med. 2024 Jan 15;209(2):223-224. doi: 10.1164/rccm.202307-1143LE. Am J Respir Crit Care Med. 2024. PMID: 37939381 Free PMC article. No abstract available.
References
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- Anzueto A, Barjaktarevic IZ, Siler TM, Rheault T, Bengtsson T, Rickard K, et al. Ensifentrine, a novel phosphodiesterase 3 and 4 inhibitor for the treatment of chronic obstructive pulmonary disease: randomized, double-blind, placebo-controlled, multicenter phase III trials (the ENHANCE trials) Am J Respir Crit Care Med . 2023;208:406–416. - PMC - PubMed
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- Boswell-Smith V, Spina D, Oxford AW, Comer MB, Seeds EA, Page CP. The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one] J Pharmacol Exp Ther . 2006;318:840–848. - PubMed
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- Rheault T, MacDonald-Berko M. Anti-inflammatory pharmacology of ensifentrine [abstract] CHEST . 2020;158:A2284.
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- Franciosi LG, Diamant Z, Banner KH, Zuiker R, Morelli N, Kamerling IM, et al. Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials. Lancet Respir Med . 2013;1:714–727. - PubMed
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