Inhaled Dual PDE3/4 Inhibitor Ensifentrine for Chronic Obstructive Pulmonary Disease: A Potential Therapeutic Perspective
- PMID: 37939381
- PMCID: PMC10806418
- DOI: 10.1164/rccm.202307-1143LE
Inhaled Dual PDE3/4 Inhibitor Ensifentrine for Chronic Obstructive Pulmonary Disease: A Potential Therapeutic Perspective
Comment in
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Reply to Gan et al., to Calzetta et al., and to Poor.Am J Respir Crit Care Med. 2024 Jan 15;209(2):226-228. doi: 10.1164/rccm.202309-1657LE. Am J Respir Crit Care Med. 2024. PMID: 37939377 Free PMC article. No abstract available.
Comment on
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Ensifentrine, a Novel Phosphodiesterase 3 and 4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease: Randomized, Double-Blind, Placebo-controlled, Multicenter Phase III Trials (the ENHANCE Trials).Am J Respir Crit Care Med. 2023 Aug 15;208(4):406-416. doi: 10.1164/rccm.202306-0944OC. Am J Respir Crit Care Med. 2023. PMID: 37364283 Free PMC article. Clinical Trial.
References
-
- Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Global Initiative for Chronic Obstructive Lung Disease; 2022. https://goldcopd.org/wp-content/uploads/2023/03/GOLD-2023-ver-1.3-17Feb2...
-
- Zuo H, Cattani-Cavalieri I, Musheshe N, Nikolaev VO, Schmidt M. Phosphodiesterases as therapeutic targets for respiratory diseases. Pharmacol Ther . 2019;197:225–242. - PubMed
-
- Anzueto A, Barjaktarevic IZ, Siler TM, Rheault T, Bengtsson T, Rickard K, et al. Ensifentrine, a novel phosphodiesterase 3 and 4 inhibitor for the treatment of chronic obstructive pulmonary disease: randomized, double-blind, placebo-controlled, multicenter phase III trials (the ENHANCE trials) Am J Respir Crit Care Med . 2023;208:406–416. - PMC - PubMed
-
- Singh D, Lea S, Mathioudakis AG. Inhaled phosphodiesterase inhibitors for the treatment of chronic obstructive pulmonary disease. Drugs . 2021;81:1821–1830. - PubMed
-
- Agusti A, Fabbri LM, Singh D, Vestbo J, Celli B, Franssen FME, et al. Inhaled corticosteroids in COPD: friend or foe? Eur Respir J . 2018;52:1801219. - PubMed
