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. 2024 Mar;271(3):1397-1407.
doi: 10.1007/s00415-023-12080-8. Epub 2023 Nov 9.

Correlation of olfactory function factors with cardiac sympathetic denervation in Parkinson's disease

Dong-Woo Ryu  1 , Sang-Won Yoo  1 , Ko-Eun Choi  1 , Yoon-Sang Oh  1 , Joong-Seok Kim  2
Affiliations

Correlation of olfactory function factors with cardiac sympathetic denervation in Parkinson's disease

Dong-Woo Ryu et al. J Neurol. 2024 Mar.

Abstract

Background: Hyposmia is a common nonmotor symptom of Parkinson's disease (PD) and reportedly associated with dysautonomia in PD. The smell identification test for measuring olfactory function consists of multiple items to discriminate specific scents. In the present study, factor analysis of the smell identification test was performed, and the correlation of extracted factors with cardiac sympathetic denervation (CSD) in patients with PD was investigated.

Methods: The present study included 183 early PD patients who underwent the Cross-Cultural Smell Identification Test (CC-SIT) and 123I-meta-iodobenzylguanidine (123I-MIBG) myocardial scintigraphy. Factor analysis of 12 items on the CC-SIT was performed using the computed correlation matrix for the binary items, and five smell factors were extracted. Multiple linear regression was performed to determine the correlation of olfactory function with late heart-to-mediastinum (H/M) ratio of 123I-MIBG uptake.

Results: The mean CC-SIT score was 6.1 ± 2.6, and 133 patients (72.7%) had CSD. The CC-SIT score and five smell factors were not associated with dopamine transporter uptake or cognitive functions. However, the CC-SIT score significantly correlated with age (P < 0.001) and late H/M ratio (P < 0.001). Factors 1 and 5 showed an increasing trend with larger H/M ratio, although it was not statistically significant (β = 0.203, P = 0.085 and β = 0.230, P = 0.085, respectively). Factor 5 significantly correlated with the H/M ratio in PD patients with CSD (β = 0.676, P = 0.036).

Discussion: The results showed olfactory dysfunction to be selectively associated with cardiac sympathetic burden in PD. The correlation of certain factors with CSD indicates the possibility of selective hyposmia in PD patients.

Keywords: 123I-meta-iodobenzylguanidine; Cardiac sympathetic denervation; Factor analysis; Olfactory function; Parkinson’s disease; Selective hyposmia; Smell identification test.

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