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. 2023 Nov 2;6(4):ooad092.
doi: 10.1093/jamiaopen/ooad092. eCollection 2023 Dec.

Creation of a data commons for substance misuse related health research through privacy-preserving patient record linkage between hospitals and state agencies

Majid Afshar  1 , Madeline Oguss  1 , Thomas A Callaci  1 , Timothy Gruenloh  1 , Preeti Gupta  2 , Claire Sun  1 , Askar Safipour Afshar  1 , Joseph Cavanaugh  1 , Matthew M Churpek  1 , Edwin Nyakoe-Nyasani  3 , Huong Nguyen-Hilfiger  3 , Ryan Westergaard  1   3 , Elizabeth Salisbury-Afshar  1   3 , Megan Gussick  1 , Brian Patterson  1 , Claire Manneh  4 , Jomol Mathew  1 , Anoop Mayampurath  1
Affiliations

Creation of a data commons for substance misuse related health research through privacy-preserving patient record linkage between hospitals and state agencies

Majid Afshar et al. JAMIA Open. .

Abstract

Objectives: Substance misuse is a complex and heterogeneous set of conditions associated with high mortality and regional/demographic variations. Existing data systems are siloed and have been ineffective in curtailing the substance misuse epidemic. Therefore, we aimed to build a novel informatics platform, the Substance Misuse Data Commons (SMDC), by integrating multiple data modalities to provide a unified record of information crucial to improving outcomes in substance misuse patients.

Materials and methods: The SMDC was created by linking electronic health record (EHR) data from adult cases of substance (alcohol, opioid, nonopioid drug) misuse at the University of Wisconsin hospitals to socioeconomic and state agency data. To ensure private and secure data exchange, Privacy-Preserving Record Linkage (PPRL) and Honest Broker services were utilized. The overlap in mortality reporting among the EHR, state Vital Statistics, and a commercial national data source was assessed.

Results: The SMDC included data from 36 522 patients experiencing 62 594 healthcare encounters. Over half of patients were linked to the statewide ambulance database and prescription drug monitoring program. Chronic diseases accounted for most underlying causes of death, while drug-related overdoses constituted 8%. Our analysis of mortality revealed a 49.1% overlap across the 3 data sources. Nonoverlapping deaths were associated with poor socioeconomic indicators.

Discussion: Through PPRL, the SMDC enabled the longitudinal integration of multimodal data. Combining death data from local, state, and national sources enhanced mortality tracking and exposed disparities.

Conclusion: The SMDC provides a comprehensive resource for clinical providers and policymakers to inform interventions targeting substance misuse-related hospitalizations, overdoses, and death.

Keywords: alcohol; data commons; health information exchange; opioids; substance abuse.

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Conflict of interest statement

None declared.

Figures

Figure 1.
Figure 1.
Data flow for substance misuse data commons.
Figure 2.
Figure 2.
Venn diagram of death data sources with nonoverlap contributions.
See this image and copyright information in PMC

References

    1. Spencer MR, Minino AM, Warner M.. Drug overdose deaths in the United States, 2001-2021. NCHS Data Brief. 2022;(457):1-8. - PubMed
    1. Yeo YH, He X, Ting PS, et al.Evaluation of trends in alcohol use disorder-related mortality in the US before and during the COVID-19 pandemic. JAMA Netw Open. 2022;5(5):e2210259. - PMC - PubMed
    1. Townsend T, Kline D, Rivera-Aguirre A, et al.Racial/ethnic and geographic trends in combined stimulant/opioid overdoses, 2007-2019. Am J Epidemiol. 2022;191(4):599-612. - PMC - PubMed
    1. US Department of Health and Human Services. Drug Abuse Warning Network, 2004: National Estimates of Drug-Related Emergency Department Visits. PsycEXTRA Dataset. 2006.
    1. Larney S, Tran LT, Leung J, et al.All-cause and cause-specific mortality among people using extramedical opioids: a systematic review and meta-analysis. JAMA Psychiatry. 2020;77(5):493-502. - PMC - PubMed

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