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. 2024 Jan;112(1):e35344.
doi: 10.1002/jbm.b.35344. Epub 2023 Nov 9.

Chitosan-sodium percarbonate-based hydrogels with sustained oxygen release potential stimulated angiogenesis and accelerated wound healing

Tayyba Sher Waris  1 , Syed Tahir Abbas Shah  2 , Azra Mehmood  3 , Afaq Mushtaq  3 , Mubashra Zehra  1 , Saima Zulfiqar  1 , Anisa Andleeb  1 , Faiza Jabbar  1 , Muhammad Awais Anjum  1 , Aqif Anwar Chaudhry  1 , Ihtesham Ur Rehman  1   4 , Muhammad Yar  1
Affiliations

Chitosan-sodium percarbonate-based hydrogels with sustained oxygen release potential stimulated angiogenesis and accelerated wound healing

Tayyba Sher Waris et al. J Biomed Mater Res B Appl Biomater. 2024 Jan.

Retraction in

Abstract

The prolonged hypoxic conditions hinder chronic wounds from healing and lead to severe conditions such as delayed re-epithelialization and enhanced risk of infection. Multifunctional wound dressings are highly required to address the challenges of chronic wounds. Herein, we report polyurethane-coated sodium per carbonate-loaded chitosan hydrogel (CSPUO2 ) as a multifunctional dressing. The hydrogels (Control, CSPU, and CSPUO2 ) were prepared by freeze gelation method and the developed hydrogels showed high porosity, good absorption capacity, and adequate biodegradability. The release of oxygen from the CSPUO2 hydrogel was confirmed by the increase in pH and a sustained oxygen release was observed over the period of 21 days, due to polyurethane (CSPU) coating. The CSPUO2 hydrogel exhibited around 2-fold increased angiogenic potential in CAM assay when compared with Control and CSPU dressing. CSPUO2 also showed good level of antibacterial efficacy against E. coli and S. aureus. In a full-thickness rat wound model, CSPUO2 hydrogel considerably accelerated wound healing with exceptional re-epithelialization granulation tissue formation less inflammatory cells and improved skin architecture highlighting the tremendous therapeutic potential of this hydrogel when compared with control and CSPU to treat chronic diabetic and burn wounds.

Keywords: angiogenesis; hypoxia; oxygen releasing hydrogel; sodium percarbonate (SPC); wound healing.

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References

REFERENCES

    1. Han G, Ceilley R. Chronic wound healing: a review of current management and treatments. Adv Ther. 2017;34:599-610.
    1. Cañedo-Dorantes L, Cañedo-Ayala M. Skin acute wound healing: a comprehensive review. Int J Inflammation. 2019;2019:1-15.
    1. Lee SJ, Heo DN, Moon JH, et al. Chitosan/polyurethane blended fiber sheets containing silver sulfadiazine for use as an antimicrobial wound dressing. J Nanosci Nanotechnol. 2014;14(10):7488-7494.
    1. Ke X, Chen C, Song Y, et al. Hypoxia modifies the polarization of macrophages and their inflammatory microenvironment, and inhibits malignant behavior in cancer cells. Oncol Lett. 2019;18(6):5871-5878.
    1. Tottoli EM, Dorati R, Genta I, Chiesa E, Pisani S, Conti B. Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics. 2020;12(8):735.

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