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Practice Guideline
. 2024 Feb;90(2):342-345.
doi: 10.1016/j.jaad.2023.08.103. Epub 2023 Nov 7.

Executive summary: Guidelines of care for the management of atopic dermatitis in adults with phototherapy and systemic therapies

Dawn M R Davis  1 , Aaron M Drucker  2 , Ali Alikhan  3 , Lionel Bercovitch  4 , David E Cohen  5 , Jennifer M Darr  6 , Lawrence F Eichenfield  7 , Lindsy Frazer-Green  8 , Amy S Paller  9 , Kathryn Schwarzenberger  10 , Jonathan I Silverberg  11 , Anne Marie Singh  12 , Peggy A Wu  13 , Robert Sidbury  14
Affiliations
Practice Guideline

Executive summary: Guidelines of care for the management of atopic dermatitis in adults with phototherapy and systemic therapies

Dawn M R Davis et al. J Am Acad Dermatol. 2024 Feb.

Abstract

Background: The summarized guidelines update the 2014 recommendations for the management of AD with phototherapy and systemic therapies.

Methods: A multidisciplinary workgroup conducted a systematic review and applied the GRADE approach for assessing the certainty of the evidence and formulating and grading recommendations.

Results: The workgroup developed 11 recommendations on the management of AD in adults with phototherapy and systemic therapies, including biologics, oral Janus Kinase inhibitors, and other immunomodulatory medications.

Conclusions: The evidence supported strong recommendations for the use of dupilumab, tralokinumab, abrocitinib, baricitinib, and upadacitinib and conditional recommendations in favor of using phototherapy, azathioprine, cyclosporine, methotrexate, and mycophenolate, and against the use of systemic corticosteroids.

Keywords: JAK inhibitor; atopic dermatitis; azathioprine; biologic; cyclosporine; dupilumab; eczema; methotrexate; phototherapy.

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Conflict of interest statement

Conflict of interest The American Academy of Dermatology (AAD) strives to produce clinical guidelines that reflect the best available evidence supplemented with the judgment of expert clinicians. Significant efforts are taken to minimize the potential for conflicts of interest to influence guideline content. The management of conflict of interest for this guideline complies with the Council of Medical Specialty Societies' Code of Interactions with Companies. Funding of guideline production by medical or pharmaceutical entities is prohibited, full disclosure is obtained and evaluated for all guideline contributors throughout the guideline development process, and recusal is used to manage identified relationships. The AAD conflict of interest policy summary may be viewed at www.aad.org.

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