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. 2023 Nov 9;75(1):92.
doi: 10.1186/s43044-023-00419-5.

Relationship between vitamin D and coronary artery disease in Egyptian patients

Magdy Algowhary  1 , Ahmed Farouk  2 , Heba E M El-Deek  3 , Ghada Hosny  3 , Ahmed Ahmed  4 , Lobna A Abdelzaher  5 , Tahia H Saleem  6
Affiliations

Relationship between vitamin D and coronary artery disease in Egyptian patients

Magdy Algowhary et al. Egypt Heart J. .

Abstract

Background: Previous studies have reported conflicting results about the association of vitamin D (VD) level with coronary artery disease (CAD). We aimed to study the association of VD with atherosclerotic CAD in Egyptian individuals.

Results: We prospectively enrolled 188 consecutive CAD patients with a median age of 55(50-62) years; 151(80.3%) were male. All patients were diagnosed by cardiac catheterization and were compared with 131 healthy controls. VD levels were measured in serum samples of all participants. Compared to controls, CAD patients had a significantly lower median VD level, 14.65 (9.25-21.45) versus 42.0 (32.0-53.0) ng/mL, p < 0.001. VD was correlated with the number of diseased coronary arteries and lipid profile (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides, p < 0.001 for each). By multivariate analyses, VD was an independent predictor of CAD [OR 1.22 (95% CI 1.07-1.4), p = 0.003, optimal cut-off value 30 ng/mL (AUC 0.92, sensitivity 81% and specificity 81.4%), p < 0.001], and the number of diseased coronary arteries, p < 0.001, especially three-vessel disease [OR 0.83 (95% CI 0.72-0.95), p = 0.008].

Conclusions: We have shown that low VD should be considered a non-traditional risk factor for CAD in Egyptian individuals. Low VD was correlated with coronary atherosclerosis, especially in patients with multivessel effects.

Keywords: Acute myocardial infarction; Coronary artery disease; Multivessel affection; Vitamin D.

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Conflict of interest statement

The author declares that there is no competing interests.

Figures

Fig. 1
Fig. 1
A Vitamin D levels according to number of diseased coronary arteries (*p < 0.001, vs. other group). B Vitamin D levels according to diseased coronary arteries and controls (*p < 0.001, vs. other groups). (Abbreviations: LAD: Left anterior descending artery, LCX: Left circumflex artery, LMT: Left main trunk, RCA: Right coronary artery)
Fig. 2
Fig. 2
Cut-off value of vitamin D to detect coronary artery disease
See this image and copyright information in PMC

References

    1. Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008;16(12):1340–1349. doi: 10.1001/archinte.168.12.1340. - DOI - PubMed
    1. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168(11):1174–1180. doi: 10.1001/archinte.168.11.1174. - DOI - PMC - PubMed
    1. Kim MH, Kim YS, Oh HJ, Kwon YR, Kim HW. The association between 10-year atherosclerotic cardiovascular diseases risk score calculated using 2013 American College of Cardiology/American Heart Association Guidelines and serum 25-hydroxyvitamin D level among aged 40–79 years in Korea: The Sixth Korea National Health and Nutrition Examination Surveys. Korean J Fam Med. 2018;39(3):174–179. doi: 10.4082/kjfm.2018.39.3.174. - DOI - PMC - PubMed
    1. Patel U, Yousuf S, Lakhani K, Raval P, Kaur N, Okafor T, et al. Prevalence and outcomes associated with vitamin D deficiency among indexed hospitalizations with cardiovascular disease and cerebrovascular disorder—a nationwide study. Medicines. 2020;7(11):72. doi: 10.3390/medicines7110072. - DOI - PMC - PubMed
    1. Apostolakis M, Armeni E, Bakas P, Lambrinoudaki I. Vitamin D and cardiovascular disease. Maturitas. 2018;115:1–22. doi: 10.1016/j.maturitas.2018.05.010. - DOI - PubMed

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