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Editorial
. 2023 Nov 10;133(11):899-901.
doi: 10.1161/CIRCRESAHA.123.323753. Epub 2023 Nov 9.

New Way to Study Pulmonary Hypertension in HFpEF

Zhiyu Dai  1   2   3   4   5 , Edward Benjamin Thorp  6
Affiliations
Editorial

New Way to Study Pulmonary Hypertension in HFpEF

Zhiyu Dai et al. Circ Res. .
No abstract available

Keywords: Editorial; heart failure; hyperlipidemia; mice; phenotypes.

PubMed Disclaimer

Conflict of interest statement

Disclosures None

Figures

Figure 1.
Figure 1.
Cellular and molecular mechanisms of PH-HFpEF development. Elevated left ventricular pressures in HFpEF patients expose the pulmonary vasculature to passive pressure elevation, leading to pulmonary venous, arterial remodeling and impairment of the capillary junction. Endothelial injury activates inflammatory and reparative responses, increasing endothelin 1 and adrenomedullin neurohormonal pathways, reducing NO and natriuretic peptide activity, promoting macrophage (Mac) accumulation and upregulation of inflammatory cytokines such as IL-6 and IL-1β, resulting in pulmonary smooth muscle cell (SMC) and fibroblast (Fib) proliferation, global pulmonary vascular remodeling, and right heart dysfunction.
See this image and copyright information in PMC

Comment on

  • Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF.
    Agrawal V, Kropski JA, Gokey JJ, Kobeck E, Murphy MB, Murray KT, Fortune NL, Moore CS, Meoli DF, Monahan K, Ru Su Y, Blackwell T, Gupta DK, Talati MH, Gladson S, Carrier EJ, West JD, Hemnes AR. Agrawal V, et al. Circ Res. 2023 Nov 10;133(11):885-898. doi: 10.1161/CIRCRESAHA.123.323119. Epub 2023 Nov 6. Circ Res. 2023. PMID: 37929582 Free PMC article.

References

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