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. 2023 Nov 20;82(12):1033-1036.
doi: 10.1093/jnen/nlad090.

Progressive supranuclear palsy can mimic idiopathic normal pressure hydrocephalus: A case series

Miki Kawazoe  1 , Shunsuke Koga  1 , Dennis W Dickson  1
Affiliations

Progressive supranuclear palsy can mimic idiopathic normal pressure hydrocephalus: A case series

Miki Kawazoe et al. J Neuropathol Exp Neurol. .
No abstract available

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Conflict of interest statement

The authors have no duality or conflicts of interest to declare.

Figures

Figure 1
Figure 1
Macroscopic and histopathologic images (Case 1: A–M, Case 2: N–Z). Case 1: Macroscopically, the brain shows no focal atrophy (A). Marked midbrain atrophy (B) with enlargement of the lateral ventricle is shown (B, C) and the subthalamic nucleus has marked atrophy and red-brown discoloration (arrow) (C). The substantia nigra has decreased pigmentation and the superior cerebellar peduncle has severe atrophy (arrowhead) with enlargement of the fourth ventricle (D). Histopathologically, the substantia nigra (E), subthalamic nucleus (F), and dentate nucleus (G) show mild to severe neuronal loss. Immunohistochemistry for phospho-tau (CP13) shows pretangles in the substantia nigra (H), subthalamic nucleus (I), and dentate nucleus (J) and shows coiled bodies in the subthalamic nucleus (I). Tufted astrocytes are seen in globus pallidus (K). The ependymal lining of the lateral ventricles (arrowhead) has severe discontinuities and mild gliosis (arrow) (L); however, no significant tau-positive deposit is seen in the ependymal lining (M). Case 2: Macroscopically, mild cortical atrophy over dorsolateral frontal lobe is found (N). Midbrain atrophy with marked enlargement of frontal horn of the lateral ventricle and the dilatation of the aqueduct of Sylvius are shown (O, P). The subthalamic nucleus has atrophy and discoloration (arrows) (P). The substantia nigra has decreased pigmentation, especially lateral parts and the superior cerebellar peduncle has mild atrophy (arrowhead) (Q). Histopathologically, the substantia nigra (R) and subthalamic nucleus (S) show moderate to severe neuronal loss and gliosis, while the dentate nucleus is relatively preserved (T). Immunohistochemistry for phospho-tau (CP13) shows pretangles in the substantia nigra (U), subthalamic nucleus (V), and dentate nucleus (W). Tufted astrocytes are seen in globus pallidus (X). The ependymal lining of the lateral ventricles (arrowhead) has severe discontinuities and mild gliosis (arrow) (Y); however, no significant tau-positive deposit is seen in the ependymal lining (Z) (tau immunohistochemistry: E, F, G, L, R, S, T, Y: H&E: H, I, J, K, M, U, V, W, X, Z). Scale bars: A–D, N–Q = 2 cm; E–K, M, R–X, Z = 200 μm; L, Y = 300 μm.
See this image and copyright information in PMC

References

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