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Review
. 2024 Feb;28(1):79-92.
doi: 10.1016/j.cld.2023.06.006. Epub 2023 Aug 12.

Primary Biliary Cholangitis: Pathophysiology

Inbal Houri  1 , Gideon M Hirschfield  2
Affiliations
Review

Primary Biliary Cholangitis: Pathophysiology

Inbal Houri et al. Clin Liver Dis. 2024 Feb.

Abstract

Primary biliary cholangitis (PBC) is the most common of the autoimmune liver diseases, in which there is chronic small bile duct inflammation. The pathophysiology of PBC is multifactorial, involving immune dysregulation and damage to biliary epithelial cells, with influences from genetic factors, epigenetics, the gut-liver axis, and environmental exposures.

Keywords: Autoimmune; Biliary epithelial cell; Epigenetics; GWAS.

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