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. 2023 Nov 24;25(46):8263-8268.
doi: 10.1021/acs.orglett.3c03308. Epub 2023 Nov 10.

Diazotization-Enabled Deaminative Late-Stage Functionalization of Primary Sulfonamides

Jiang-Sheng Li  1 , Jia Liu  1 , Yao-Tian Wang  1 , Jia-Ying Dai  1 , Zhi-Wei Li  1 , Wei-Wei Luo  1 , Yue-Fei Zhang  1 , Han-Wen Liu  1 , Wei-Dong Liu  2
Affiliations

Diazotization-Enabled Deaminative Late-Stage Functionalization of Primary Sulfonamides

Jiang-Sheng Li et al. Org Lett. .

Abstract

We, for the first time, disclosed a simple and efficient strategy for the late-stage functionalization of primary sulfonamides by diazotization, leading to sulfonyl chlorides, sulfonates, and complex sulfonamides. This protocol obviates the requirement for the prefunctionalization of sulfonamides. Its applicability is exemplified by the late-stage functionalization of sulfonamide-type drugs.

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