Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 5;12(21):2576.
doi: 10.3390/cells12212576.

A Brief Review of Bone Cell Function and Importance

Veronika Šromová  1   2 , Dinara Sobola  3 , Pavel Kaspar  2
Affiliations
Review

A Brief Review of Bone Cell Function and Importance

Veronika Šromová et al. Cells. .

Abstract

This review focuses on understanding the macroscopic and microscopic characteristics of bone tissue and reviews current knowledge of its physiology. It explores how these features intricately collaborate to maintain the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption, which plays a pivotal role in shaping not only our physical framework but also overall health. In this work, a comprehensive exploration of microscopic and macroscopic features of bone tissue is presented.

Keywords: bone cells; microscopic and macroscopic intricacies; physiology of bone tissue.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Distribution of bone matrix components.
Figure 2
Figure 2
Osteoclast sealing zone formation and proton transport.
Figure 3
Figure 3
Differences in osteoblastogenesis and osteoclastogenesis.
Figure 4
Figure 4
Osteoblast and osteoclast differentiation and life cycle before apoptosis.
Figure 5
Figure 5
Osteoblast transitions after bone-forming phase.
Figure 6
Figure 6
The cell body of osteocyte located in lacuna, and the cytoplasmic processes are situated in canaliculi.
Figure 7
Figure 7
Effect of RANKL on osteoclastogenesis.
Figure 8
Figure 8
Activated Wnt signaling pathway: (1) the Wnt ligand binds to Frizzled and LRP5/6 receptors; (2) Frizzled interacts with Disheveled (Dsh); (3) β-catenin translocates into the nucleus; (4) β-catenin forms a complex with various enhanceosome proteins.
Figure 9
Figure 9
The structure of Haversian system (osteon). Each osteon contains a single central Haversian canal encircled by concentric lamellae.
Figure 10
Figure 10
Structure of a long bone. The distal and proximal ends (epiphyses) are separated from the shaft (diaphysis) by metaphyses.
Figure 11
Figure 11
Zones of endochondral ossification.
See this image and copyright information in PMC

References

    1. Standring S. 40th ed. Churchill Livingstone Elsevier; London, UK: 2008. Gray’s Anatomy: The Anatomical Basis of Clinical Practice.
    1. Bordoni B., Black A.C., Varacallo M. StatPearls. StatPearls Publishing; Treasure Island, FL, USA: [(accessed on 30 August 2023)]. Anatomy, Tendons. Available online: https://www.ncbi.nlm.nih.gov/books/NBK513237. - PubMed
    1. U.S. Department of Health and Human Services . Bone Health and Osteoporosis: A Report of the Surgeon General. U.S. Department of Health and Human Services, Office of the Surgeon General; Rockville, MD, USA: 2004. [(accessed on 30 August 2023)]. Available online: https://www.ncbi.nlm.nih.gov/books/NBK45513.
    1. Shaker J.L., Deftos M.D. Calcium and Phosphate Homeostasis. Endocr. Reprod. Physiol. [(accessed on 30 August 2023)];2023 Available online: https://www.ncbi.nlm.nih.gov/books/NBK279023.
    1. Kovacs E.J. Wheater’s Functional Histology: A Text and Colour Atlas. Arch. Pathol. Lab. Med. 2001;125:708. doi: 10.5858/2001-125-708b-WFHATA. - DOI

Publication types

LinkOut - more resources