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. 2023 Oct 28;12(10):piad099.
doi: 10.1093/jpids/piad099.

Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures

Bahaa Abu-Raya  1   2 , Frederic Reicherz  1   2   3 , Christina Michalski  1   2 , Marina Viñeta Paramo  1   2 , Abdelilah Majdoubi  1   2 , Liam Golding  1   2 , Madison Granoski  4 , Aleksandra Stojic  4 , David J Marchant  4 , Pascal M Lavoie  1   2
Affiliations

Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures

Bahaa Abu-Raya et al. J Pediatric Infect Dis Soc. .

Abstract

Studies have linked respiratory syncytial virus (RSV) antibody-mediated phagocytosis and complement deposition to severe RSV infection in humans. This study shows waning of these antibody functions in women of childbearing age in 2020-2021 during the implementation of COVID-19 mitigation measures, in absence of RSV circulation. These functions could be explored as correlates of protection against severe RSV disease.

Keywords: COVID-19; Fc-mediated function; RSV; RSV hiatus; immunity debt.

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