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Review
. 2023 Dec:83:102728.
doi: 10.1016/j.sbi.2023.102728. Epub 2023 Nov 9.

Mechanical forces and the 3D genome

G V Shivashankar  1
Affiliations
Review

Mechanical forces and the 3D genome

G V Shivashankar. Curr Opin Struct Biol. 2023 Dec.

Abstract

Traditionally, the field of genomics has been studied from a biochemical perspective. Besides chemical influences, cells are subject to a variety of mechanical signals from their surrounding tissue microenvironment. These mechanical signals can not only cause changes to a cell's physical structure but can also lead to alterations in their genomes and gene expression programs. Understanding the mechanical control of genome organization and expression may provide a new perspective on gene regulation.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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