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. 2024 Feb;49(2):101-104.
doi: 10.1016/j.tibs.2023.10.002. Epub 2023 Nov 8.

Dissecting the biophysics and biology of intrinsically disordered proteins

Priya R Banerjee  1 , Alex S Holehouse  2 , Richard Kriwacki  3 , Paul Robustelli  4 , Hao Jiang  5 , Alexander I Sobolevsky  6 , Jennifer M Hurley  7 , Joshua T Mendell  8
Affiliations

Dissecting the biophysics and biology of intrinsically disordered proteins

Priya R Banerjee et al. Trends Biochem Sci. 2024 Feb.

Abstract

Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.

Keywords: cancer; condensates; phase separation; single-molecule microscopy.

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Conflict of interest statement

Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1:
Figure 1:
Emerging paradigm and current challenges in sequence-ensemble-function relationships of intrinisically disordered proteins.
See this image and copyright information in PMC

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