Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb;1871(2):119529.
doi: 10.1016/j.bbamcr.2023.119529. Epub 2023 Nov 9.

Mitochondrial entry gate as regulatory hub

Fabian den Brave  1 , Nikolaus Pfanner  2 , Thomas Becker  3
Affiliations
Free article
Review

Mitochondrial entry gate as regulatory hub

Fabian den Brave et al. Biochim Biophys Acta Mol Cell Res. 2024 Feb.
Free article

Abstract

Mitochondria import 1000-1300 different precursor proteins from the cytosol. The main mitochondrial entry gate is formed by the translocase of the outer membrane (TOM complex). Molecular coupling and modification of TOM subunits control and modulate protein import in response to cellular signaling. The TOM complex functions as regulatory hub to integrate mitochondrial protein biogenesis and quality control into the cellular proteostasis network.

Keywords: Mitochondria; Protein sorting; Proteostasis; Quality control; Stress response; TOM complex.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Publication types

MeSH terms

Substances

LinkOut - more resources