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Editorial
. 2023 Nov 2;164(12):bqad166.
doi: 10.1210/endocr/bqad166.

Paradigm Shift in the Management of Metabolic Diseases-Next-Generation Incretin Therapy

Bo Ahrén  1
Affiliations
Editorial

Paradigm Shift in the Management of Metabolic Diseases-Next-Generation Incretin Therapy

Bo Ahrén. Endocrinology. .

Abstract

Recently impressive weight loss has been reported for novel incretin therapies based on dual-and triple-hormone receptor coagonists. These agents have potential as being positioned as early therapeutics for metabolic diseases for which weight loss is preferred, such as type 2 diabetes, obesity, cardiovascular diseases, and nonalcoholic liver disease. This development will change the landscape of future therapy and also place weight reduction at the centerpiece for therapy of metabolic diseases.

Keywords: GIP; GLP-1; coagonists; glucagon; obesity; type 2 diabetes.

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