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. 2024 Feb;103(2):565-574.
doi: 10.1007/s00277-023-05536-4. Epub 2023 Nov 11.

25-Hydroxy vitamin D deficiency is an inferior predictor of peripheral T-cell lymphomas

Hao-Rui Shen #  1   2   3 , Jing Tang #  1   2   3 , Wen-Yi Li #  1   2   3 , Jin-Hua Liang  1   2   3 , Yue Li  1   2   3 , Jia-Zhu Wu  1   2   3 , Li Wang  1   2   3 , Jian-Yong Li  1   2   3 , Rui Gao  4 , Hua Yin  5   6   7 , Wei Xu  8   9   10
Affiliations

25-Hydroxy vitamin D deficiency is an inferior predictor of peripheral T-cell lymphomas

Hao-Rui Shen et al. Ann Hematol. 2024 Feb.

Abstract

The aim of the study was to explore the significance and prognostic value of 25-hydroxy vitamin D (25-(OH) D) deficiency in peripheral T-cell lymphomas (PTCLs). One hundred fifty-six patients of newly diagnosed PTCLs were enrolled in the study. Univariate and multivariate regression analyses were performed to determine independent risk factors for progression-free survival (PFS) and overall survival (OS). Receiver operating characteristic (ROC) curves were plotted, and corresponding areas under the curve (AUC) were calculated to estimate the accuracy of International Prognostic Index (IPI) plus 25-(OH) D deficiency and Prognostic Index for T-cell lymphoma (PIT) plus 25-(OH) D deficiency respectively in PTCL risk stratification. Our results showed that the 25-(OH) D deficiency was an independent inferior prognostic factor for both PFS (P = 0.0019) and OS (P = 0.005) for PTCLs, especially for AITL and PTCL-not otherwise specified (PTCL-NOS). Additionally, adding 25-(OH) D deficiency to PIT indeed has a superior prognostic significance than PIT alone for PFS (P = 0.043) and OS (P = 0.036). Multivariate COX regression analysis revealed that PIT 2‒4, albumin (ALB) ≤ 35 g/L, and 25-(OH) D deficiency were regarded as independent risk factors of PFS and OS. Our results showed that 25-(OH) D deficiency was associated with inferior survival outcome of PTCLs, especially for AITL and PTCL-NOS. PIT plus 25-(OH) D deficiency could better indicate the prognosis for PFS and OS of PTCLs than PIT.

Keywords: 25-(OH)D deficiency; Peripheral T-cell lymphomas; Prognosis; Survival.

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