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Review
. 2023 Oct 17;9(11):e21106.
doi: 10.1016/j.heliyon.2023.e21106. eCollection 2023 Nov.

Metabolic syndrome: Nutri-epigenetic cause or consequence?

Alfonso D Silva-Ochoa  1   2 , Erick Velasteguí  1   3 , Isaac B Falconí  1 , Valeria I García-Solorzano  1 , Angie Rendón-Riofrio  1 , Gabriela A Sanguña-Soliz  1   4 , Wim Vanden Berghe  5 , Andrea Orellana-Manzano  1
Affiliations
Review

Metabolic syndrome: Nutri-epigenetic cause or consequence?

Alfonso D Silva-Ochoa et al. Heliyon. .

Abstract

Metabolic syndrome is a cluster of conditions that results from the interplay of genetic and environmental factors, which increase the comorbidity risk of obesity, hyperglycemia, dyslipidemia, arterial hypertension, stroke, and cardiovascular disease. In this article, we review various high-impact studies which link epigenetics with metabolic syndrome by comparing each study population, methylation effects, and strengths and weaknesses of each research. We also discuss world statistical data on metabolic syndrome incidence in developing countries where the metabolic syndrome is common condition that has significant public health implications.

Keywords: Diabetes; Epigenetics; Metabolic syndrome; Nutrition; Obesity.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Correlation between the bioactive compounds, diet, and epigenetics modification in metabolic syndrome. The presence or absence of nutrients and bioactive compounds in the diet has been associated with epigenetic modifications in genes that regulate metabolic processes such as CORO7, PCSK, miRNAs, UPC1, and ACE. These genes' influence could lead to the predisposition to develop metabolic disorders and cancer.
See this image and copyright information in PMC

References

    1. Wang J., Wu Z., Li D., Li N., Dindot S.V., Satterfield M.C., et al. Nutrition, epigenetics, and metabolic syndrome. Antioxidants Redox Signal. 2012 Jul 15;17(2):282–301. doi: 10.1089/ars.2011.4381. - DOI - PMC - PubMed
    1. Stocks T., Bjørge T., Ulmer H., Manjer J., Häggström C., Nagel G., et al. Metabolic risk score and cancer risk: pooled analysis of seven cohorts. Int. J. Epidemiol. 2015 Aug;44(4):1353–1363. doi: 10.1093/ije/dyv001. - DOI - PMC - PubMed
    1. Ji Y., Wu Z., Dai Z., Sun K., Wang J., Wu G. Nutritional epigenetics with a focus on amino acids: implications for the development and treatment of metabolic syndrome. J. Nutr. Biochem. 2016;27:1–8. doi: 10.1016/j.jnutbio.2015.08.003. - DOI - PubMed
    1. Lin G., Wang X., Wu G., Feng C., Zhou H., Li D., et al. Improving amino acid nutrition to prevent intrauterine growth restriction in mammals. Amino Acids. 2014;46(7):1605–1623. doi: 10.1007/s00726-014-1725-z. - DOI - PubMed
    1. Lu Q., Qiu X., Hu N., Wen H., Su Y., Richardson B.C. Epigenetics, disease, and therapeutic interventions. Ageing Res. Rev. 2006;5(4):449–467. doi: 10.1016/j.arr.2006.07.001. - DOI - PubMed

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