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Case Reports
. 2023 Oct 22;9(11):e21204.
doi: 10.1016/j.heliyon.2023.e21204. eCollection 2023 Nov.

Pediatric gliosarcoma, a rare central nervous system tumor in children: Case report and literature review

Jinyan Chen  1 , Dong He  1 , Gengyin Guo  1 , Keke Zhang  2 , Wenliang Sheng  3 , Zhen Zhang  1
Affiliations
Case Reports

Pediatric gliosarcoma, a rare central nervous system tumor in children: Case report and literature review

Jinyan Chen et al. Heliyon. .

Abstract

Gliosarcoma is a rare and highly malignant central nervous system tumor that accounts for 1%-8% of glioblastomas; it usually occurs in middle-aged and older adults between 40 and 60 years of age and is rare in children. We report an 11-year-old boy with right frontal lobe gliosarcoma who underwent aggressive gross total resection and postoperative radiotherapy, experienced recurrence and subsequently underwent a second operation. To better understand the disease and explore treatment options, we briefly report this case and review the relevant literature.

Keywords: Cerebral hemispheres; Glioblastoma; Gliosarcoma; Pediatric; Surgery.

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Conflict of interest statement

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Preoperative MRI: (A) axial T1 image; (B), axial T2 image; (C), axial T2-FLAIR image; (D), axial T1-weighted image with gadolinium contrast; (E) coronal T1-weighted image with gadolinium contrast; (F) sagittal T1-weighted image with gadolinium contrast. Postoperative MRI: (G) axial T1 image; (H) axial T2 image; (I) axial T2-FLAIR image; (G) axial T1-weighted image with gadolinium contrast; (K) coronal T1-weighted image with gadolinium contrast; (L) sagittal T1-weighted image with gadolinium contrast.
Fig. 2
Fig. 2
Postoperative pathology: (A) Glioblastoma area; (B) Sarcoma area(C) The spindle cell bundle is a sarcoma with interspersed glioblastoma components.
Fig. 3
Fig. 3
Eight-month postoperative MRI: (A) axial T1 image; (B) axial T2 image; (C) axial T2-FLAIR image; (D) axial T1-weighted image with gadolinium contrast; (E) coronal T1-weighted image with gadolinium contrast; (F) sagittal T1-weighted image with gadolinium contrast; (G) second postoperative CT; (H) post–V-P bypass CT.
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