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. 2023 Nov 7:16:3333-3338.
doi: 10.2147/JMDH.S432458. eCollection 2023.

Impact of Thrombolysis Time Metrics When Participating in National Stroke Center Construction Project

Wanchun Cheng  1 , Mohammad Mofatteh  2 , José Fidel Baizabal-Carvallo  3   4 , Shaohuan Lu  1 , Ping Su  1 , Yimin Chen  5   6 , Luoming Li  1 , Lizhi Qin  1 , Xingmei Zuo  1 , Yifeng Lan  7 , Yue Huang  8 , Zhihui Yu  9 , Zirui Luo #  10 , Gang Chen #  10
Affiliations

Impact of Thrombolysis Time Metrics When Participating in National Stroke Center Construction Project

Wanchun Cheng et al. J Multidiscip Healthc. .

Abstract

Purpose: Intravenous thrombolysis has emerged as an effective approach to improve the long-term survival and functional status of patients with ischemic stroke. The aim of this study was to assess the impact of a national stroke project on the door-to-needle-time (DNT).

Patients and methods: The patients were divided into pre-construction and construction periods. Construction Measures were performed during the construction period. The DNT and onset-to-needle time (ONT) were compared in two period groups.

Results: After participating in the National Stroke Center Project and effective measurements, the thrombolysis treatment metrics were improved significantly. The DNT (IQR) was shortened from 65.0 (54.5,85.0) minutes in the Pre-Construction period to 40.0 (33.0,53.0) minutes in the Construction period (p < 0.001). Similarly, the ONT was reduced from 157.0 (IQR) (115.0,184.0) minutes to 116.0 (87.8,170.0) minutes (p = 0.035).

Conclusion: The DNT time and ONT time can be shortened by National Stroke Center Construction projects. More suitable hospitals should be encouraged to participate as the National Stroke Center.

Keywords: acute ischemic stroke; door-to-needle time; intravenous thrombolysis; onset-to-needle time.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

References

    1. Burnier M, Fricker AF, Hayoz D, et al. Pharmacokinetic and pharmacodynamic effects of YM087, a combined V1/V2 vasopressin receptor antagonist in normal subjects. Eur J Clin Pharmacol. 1999;55:633–637. doi:10.1007/s002280050685 - DOI - PubMed
    1. Muruet W, Rudd A, Wolfe CDA, Douiri A. Long-Term Survival After Intravenous Thrombolysis for Ischemic Stroke: a Propensity Score-Matched Cohort With up to 10-Year Follow-Up. Stroke. 2018;49(3):607–613. doi:10.1161/strokeaha.117.019889 - DOI - PMC - PubMed
    1. Rajan SS, Decker-Palmer M, Wise J, Dao T, Salem C, Savitz SI. Beneficial effects of the 30-minute door-to-needle time standard for alteplase administration. Ann Clin Transl Neurol. 2021;8(8):1592–1600. doi:10.1002/acn3.51400 - DOI - PMC - PubMed
    1. Nguyen TN, Fischer U. Treatment Effect of Intravenous Thrombolysis Bridging to Mechanical Thrombectomy on Vessel Occlusion Site. Stroke. 2022;53(1):17–19. doi:10.1161/strokeaha.121.037603 - DOI - PubMed
    1. Masoud HE, de Havenon A, Castonguay AC, et al. 2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: a Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee. Stroke. 2022;2(4):e000276. doi:10.1161/SVIN.121.000276 - DOI