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. 2023 Nov 8:16:11795514231206729.
doi: 10.1177/11795514231206729. eCollection 2023.

Osteocalcin and Metabolic Syndrome

Aaditya Viswanath  1 , Sudha Vidyasagar  1 , Cynthia Amrutha Sukumar  1
Affiliations

Osteocalcin and Metabolic Syndrome

Aaditya Viswanath et al. Clin Med Insights Endocrinol Diabetes. .

Abstract

Introduction: Metabolic syndrome which is a syndrome complex that is associated with insulin resistance. Osteocalcin (OC), a bone derived protein has been found to decrease insulin resistance and stimulate production of insulin from the pancreas. Serum osteocalcin levels correlate with body mass index (BMI) and waist circumference. Thus, serum osteocalcin levels in metabolic syndrome could potentially be a new area to explore therapeutically. However, its role in clinical practice needs to be established.

Methods: We conducted a cross-sectional study on patients, who visited Kasturba Hospital, Manipal between September 2018 and September 2020, to study the relationship between Serum Osteocalcin and the parameters of metabolic syndrome. All patients above the age of 18 years who satisfied the NCEP-ATP III guidelines (Asian adaptation) for metabolic syndrome were considered for the study. Patients who had thyroid and parathyroid disorders, bone malignancies, osteoporosis, liver failure and renal dysfunction were excluded.

Results: A total of 115 subjects were analyzed. As serum osteoclacin increased, there was a significant decrease in fasting blood glucose levels (r = -.748, P < .05) and a significant increase in serum HDL levels (r = .617, P < .01). There was no correlation found between serum osteocalcin and BMI/waist circumference in this study. Finally, it was observed that individuals with fewer components of metabolic syndrome had a significantly higher serum osteocalcin when compared with individuals with a higher number of components of metabolic syndrome (P < .01).

Conclusion: This data further confirmed the association between serum OC and parameters of metabolic syndrome such as FBS and serum HDL. It also found that increased serum OC was associated with fewer components of the metabolic syndrome indicating that OC could have a positive metabolic impact and may prevent atherosclerotic risk.

Keywords: Osteocalcin; body mass index; insulin resistance; metabolic syndrome; syndrome X; waist circumference.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Representation of baseline parameters of metabolic syndrome.
Figure 2.
Figure 2.
Scatter plot showing the correlation between serum osteocalcin and BMI.
Figure 3.
Figure 3.
Scatterplot showing the correlation of serum osteocalcin with waist circumference in females.
Figure 4.
Figure 4.
Scatterplot showing the correlation of serum osteocalcin and waist circumference in males.
Figure 5.
Figure 5.
Scatter plot showing the correlation of fasting blood glucose with serum osteocalcin.
Figure 6.
Figure 6.
Scatter plot of the correlation of osteocalcin and HDL.
Figure 7.
Figure 7.
Scatterplot showing correlation between serum osteocalcin and triglycerides.
Figure 8.
Figure 8.
Boxplot showing the correlation between serum osteocalcin and components of metabolic syndrome.
See this image and copyright information in PMC

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