Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 5;24(21):15987.
doi: 10.3390/ijms242115987.

Developments in Genetics: Better Management of Ovarian Cancer Patients

Ovidiu-Virgil Maioru  1 , Viorica-Elena Radoi  1   2 , Madalin-Codrut Coman  1 , Iulian-Andrei Hotinceanu  1 , Andra Dan  1 , Anca-Elena Eftenoiu  1 , Livia-Mălina Burtavel  1 , Laurentiu-Camil Bohiltea  1   2 , Emilia-Maria Severin  1
Affiliations
Review

Developments in Genetics: Better Management of Ovarian Cancer Patients

Ovidiu-Virgil Maioru et al. Int J Mol Sci. .

Abstract

The purpose of this article is to highlight the new advancements in molecular and diagnostic genetic testing and to properly classify all ovarian cancers. In this article, we address statistics, histopathological classification, molecular pathways implicated in ovarian cancer, genetic screening panels, details about the genes, and also candidate genes. We hope to bring new information to the medical field so as to better prevent and diagnose ovarian cancer.

Keywords: diagnosis; genetics; molecular; ovarian; panel; pathways; screening.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
BRCA1 and BRCA2 pathway.
Figure 2
Figure 2
MAPK/ERK pathway.
Figure 3
Figure 3
PI3K/AKT/MTOR signaling pathway.
Figure 4
Figure 4
WNT/β-catenin signaling pathway.
Figure 5
Figure 5
JAK/STAT pathway.
Figure 6
Figure 6
MET/HGF signaling pathway.
Figure 7
Figure 7
Notch pathway.
Figure 8
Figure 8
RAS signaling pathway.
See this image and copyright information in PMC

References

    1. [(accessed on 20 August 2023)]. Available online: https://gco.iarc.fr/
    1. [(accessed on 20 August 2023)]. Available online: https://gco.iarc.fr/tomorrow/en/dataviz/trends?types=0_1&sexes=2&mode=po....
    1. [(accessed on 20 August 2023)]; Available online: https://seer.cancer.gov/statfacts/html/ovary.html.
    1. America Cancer Society Key Statistics for Ovarian Cancer. [(accessed on 20 August 2023)]. Available online: https://www.cancer.org/cancer/types/ovarian-cancer/about/key-statistics....
    1. McLemore M.R., Miaskowski C., Aouizerat B.E., Dodd M.J. Epidemiologic and Genetic Factors Associated with Ovarian Cancer. Cancer Nurs. 2009;32:281. doi: 10.1097/NCC.0b013e31819d30d6. - DOI - PMC - PubMed