Role of Fisetin in Selected Malignant Neoplasms in Women

Abstract

A promising therapeutic window and cost-effectiveness are just two of the potential advantages of using naturally derived drugs. Fisetin (3,3',4',7-tetrahydroxyflavone) is a natural flavonoid of the flavonol group, commonly found in fruit and vegetables. In recent years, fisetin has gained wide attention across the scientific community because of its broad spectrum of pharmacological properties, including cytotoxic activity against most abundant cancers. By stimulating or inhibiting selected molecular targets or biochemical processes, fisetin could affect the reduction of metastasis or cancer progression, which indicates its chemotherapeutic or chemopreventive role. In this review, we have summarized the results of studies on the anticancer effects of fisetin on selected female malignancies, both in in vitro and in vivo tests, i.e., breast, cervical, and ovarian cancer, published over the past two decades. Until now, no article dedicated exclusively to the action of fisetin on female malignancies has appeared. This review also describes a growing number of nanodelivery systems designed to improve the bioavailability and solubility of this natural compound. The reported low toxicity and activity of fisetin on cancer cells indicate its valuable potential, but large-scale clinical trials are urgently needed to assess real chemotherapeutic efficacy of this flavonoid.

Keywords: breast cancer; cervical cancer; fisetin; flavonoids; flavonols; in vitro activity; in vivo activity; nanodelivery systems; ovarian cancer.

Figure 1

Structure of flavonoids and selected representatives of each of their six subclasses.

Figure 2

(A) Structure of fisetin, (B) fisetin content in fruits and vegetables, (C) selected molecular targets/processes stimulated (green) or inhibited (red) by fisetin.

Figure 3

Summary of the anticancer activities of fisetin in selected malignant neoplasms in women. Abbreviations used: HER-2, human epidermal growth factor receptor 2; MMP, matrix metalloproteinase; uPA, urokinase-type plasminogen activator.