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Review
. 2024 Mar;44(2):131-135.
doi: 10.1111/cpf.12865. Epub 2023 Nov 14.

A case of hemichorea associated with nonketotic hyperglycaemia: A new magnetic resonance spectroscopy (MRS) finding and possible future implications

Assunta Trinchillo  1 , Flavio Barchetti  2 , Gabriella De Joanna  3 , Marcello Esposito  4 , Giovanni Piccirillo  3 , Stefania Miniello  3
Affiliations
Review

A case of hemichorea associated with nonketotic hyperglycaemia: A new magnetic resonance spectroscopy (MRS) finding and possible future implications

Assunta Trinchillo et al. Clin Physiol Funct Imaging. 2024 Mar.

Abstract

Background: Diabetic Striatopathy (DS) is a rare complication of a poor-controlled Diabetes Mellitus consisting of sudden onset of movement disorders. To date, there is still poor knowledge about the pathogenesis.

Case: We describe a 79 year old men affected by sudden onset hemichoreic movements whose cause was a non-ketotic hyperglycaemia diagnosed despite the normal blood glucose levels thanks to brain CT and magnetic resonance imaging. Then, we introduce a new magnetic resonance spectroscopy (MRS) finding never described until today which allowed us to produce a new pathogenetic theory of a phenomenon still without definitive explanations.

Literature review: We performed a review of DS cases using the Medline database and we extracted main data regarding imaging findings.

Conclusions: Thanks to our MRS we show new imaging findings never described until today, with a new pathogenetic explanation, since all the causative hypotheses produced during the past years have never found evidence.

Keywords: Diabetic Striatopathy (DS); MR spectroscopy; hemichorea/hemiballism; movement disorders.

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References

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