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. 2023 Dec 14;67(12):e0082923.
doi: 10.1128/aac.00829-23. Epub 2023 Nov 14.

Isavuconazole use and TDM in real-world pediatric practice

Berta Fernández Ledesma  1 , Natalia Mendoza-Palomar  1 , Susana Melendo Pérez  1 , Aurora Fernández-Polo  2 , Berta Renedo Miró  2 , Alba Pau Parra  2 , Sonia Luque Pardos  3 , Santiago Grau Cerrato  3 , Jaume Vima Bofarull  4 , María Teresa Martín-Gómez  5 , Montserrat Pujol Jover  6 , Maria Isabel Benítez-Carbante  7 , Cristina Díaz de Heredia  7 , Pere Soler-Palacin  8
Affiliations

Isavuconazole use and TDM in real-world pediatric practice

Berta Fernández Ledesma et al. Antimicrob Agents Chemother. .

Abstract

Isavuconazole (ISA) is approved for treating invasive aspergillosis and mucormycosis in adults, but its use in children remains off-label. We report on the use of ISA in real-world pediatric practice with 15 patients receiving ISA for treatment of invasive fungal infections. Therapeutic drug monitoring (TDM) was performed in all patients, with 52/111 (46.8%) Ctrough determinations out of range, thus supporting the need for TDM in children, especially those receiving extracorporeal membrane oxygenation (ECMO).

Keywords: ECMO; children; invasive fungal infection; isavuconazole; targeted drug monitoring.

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Conflict of interest statement

The authors declare no conflict of interest.

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