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. 2023 Dec 12;11(6):e0277223.
doi: 10.1128/spectrum.02772-23. Epub 2023 Nov 14.

Real-world evaluation of the Lucira Check-It COVID-19 loop-mediated amplification (LAMP) test

Elizabeth Simms  1   2   3 , Gregory R McCracken  3 , Todd F Hatchette  1   2   3 , Shelly A McNeil  1 , Ian Davis  1   2   3 , Noella Whelan  4 , Angela Keenan  5 , Jason J LeBlanc  1   2   3 , Glenn Patriquin  1   2   3
Affiliations

Real-world evaluation of the Lucira Check-It COVID-19 loop-mediated amplification (LAMP) test

Elizabeth Simms et al. Microbiol Spectr. .

Abstract

In hospitals during the COVID-19 pandemic, laboratory testing was important to reduce SARS-CoV-2 transmissions, while facilitating patient flow in the emergency department and pre-operative settings, and allowing for the safe return to work of exposed healthcare workers. Delayed test results from laboratory nucleic acid amplification tests (NAATs) posed a barrier to maximizing efficient patient flow and minimizing staffing shortages. This quality improvement project sought to evaluate the analytical and clinical performance of the Lucira Check-It COVID-19 Test, a point-of-care test that used NAAT technology, in the perioperative setting, emergency department, and community testing sites. We found the Lucira Check-It to have comparable performance to laboratory NAATs. It can be employed with little training for specimen collection, processing, and interpretation, and at a cost justifiable from the resources saved from avoiding sample transport and laboratory testing.

Keywords: COVID-19; SARS-CoV-2; diagnostic; loop-mediated amplification (LAMP); point-of-care (POC).

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Keri VC, Brunda RL, Jorwal P, Sethi P, Wig N. 2021. Decentralizing COVID-19 care-moving towards a COVID-19-capable healthcare system (CCHS). Int J Health Plann Manage 36:1355–1361. doi: 10.1002/hpm.3158 - DOI - PMC - PubMed
    1. Maltezou HC, Dedoukou X, Tseroni M, Tsonou P, Raftopoulos V, Papadima K, Mouratidou E, Poufta S, Panagiotakopoulos G, Hatzigeorgiou D, Sipsas N. 2020. SARS-Cov-2 infection in healthcare personnel with high-risk occupational exposure: evaluation of 7-day exclusion from work policy. Clin Infect Dis 71:3182–3187. doi: 10.1093/cid/ciaa888 - DOI - PMC - PubMed
    1. Safiabadi Tali SH, LeBlanc JJ, Sadiq Z, Oyewunmi OD, Camargo C, Nikpour B, Armanfard N, Sagan SM, Jahanshahi-Anbuhi S. 2021. Tools and techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/COVID-19 detection. Clin Microbiol Rev 34:e00228-20. doi: 10.1128/CMR.00228-20 - DOI - PMC - PubMed
    1. Zahavi M, Rohana H, Azrad M, Shinberg B, Peretz A. 2022. Rapid SARS-CoV-2 detection using the Lucira check it COVID-19 test kit. Diagnostics (Basel) 12:1877. doi: 10.3390/diagnostics12081877 - DOI - PMC - PubMed
    1. LeBlanc JJ, McCracken GR, Goodall B, Hatchette TF, Barrett L, Ross J, Davidson RJ, Patriquin G. 2022. Avoiding false-positive SARS-CoV-2 rapid antigen test results with point-of-care molecular testing on residual test buffer. Microbiol Spectr 10:e0063922. doi: 10.1128/spectrum.00639-22 - DOI - PMC - PubMed