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. 2024 Jun;17(3):657-668.
doi: 10.1007/s12265-023-10457-8. Epub 2023 Nov 14.

Slow-Reflow and Prognosis in Patients with High Parathyroid Hormone Levels Undergoing Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction

Gangyong Wu #  1   2 , Zufei Wu #  3   4 , Baida Xu #  3   5 , Shi Chen  3   5 , Wentao Su  3   5 , Yehong Liu  3   5 , Ting Wu  3   5 , Qin Shen  3   5 , Gangjun Zong  6   7
Affiliations

Slow-Reflow and Prognosis in Patients with High Parathyroid Hormone Levels Undergoing Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction

Gangyong Wu et al. J Cardiovasc Transl Res. 2024 Jun.

Abstract

We aimed to evaluate the correlation among serum parathyroid hormone (PTH) and slow-reflow during primary percutaneous coronary intervention (PCI) and prognosis in patients with ST-segment elevation myocardial infarction (STEMI). A total of 262 patients were enrolled and divided into a slow-reflow group (n = 61) and a control group (n = 201). PTH was an independent risk factor for slow-reflow (P < 0.05), and the regression model had good discrimination and calibration. ROC curve analysis showed that PTH (≥ 63.65 pg/ml) had a predictive value for slow-reflow (P < 0.001). During the 1-year follow-up, the patients were divided into a PTH-h group (≥ 63.65 pg/ml, n = 100) and a PTH-l group (< 63.65 pg/ml, n = 162). Readmission for HF was independently associated with PTH levels (P < 0.05). KM survival analysis suggested that PTH-h had a predictive value for MACEs, especially for readmission for HF (P < 0.05). PTH levels were associated with slow-reflow during PCI and MACEs during follow-up in patients with STEMI.

Keywords: Acute ST-segment elevation myocardial infarction; Major adverse cardiovascular events; Parathyroid hormone; Percutaneous coronary intervention; Prognosis; Slow-reflow.

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