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Review
. 2024 Jan 1;39(1):0.
doi: 10.1152/physiol.00021.2023. Epub 2023 Nov 14.

Microglia in Central Control of Metabolism

Jung Dae Kim  1 , Francesca Copperi  1 , Sabrina Diano  1   2   3
Affiliations
Review

Microglia in Central Control of Metabolism

Jung Dae Kim et al. Physiology (Bethesda). .

Abstract

Beyond their role as brain immune cells, microglia act as metabolic sensors in response to changes in nutrient availability, thus playing a role in energy homeostasis. This review highlights the evidence and challenges of studying the role of microglia in metabolism regulation.

Keywords: diet-induced obesity; glial; hypothalamus; metabolism.

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Conflict of interest statement

S. Diano is an editor of Physiology and was not involved and did not have access to information regarding the peer-review process or final disposition of this article. An alternate editor oversaw the peer-review and decision-making process for this article. None of the other authors has any conflicts of interest, financial or otherwise, to disclose.

Figures

FIGURE 1.
FIGURE 1.
Hypothalamic microglia activation during high-fat diet (HFD) Microglia response to changes in dietary molecules and hormones [leptin, glucagon-like peptide 1 (GLP-1), adiponectin, ghrelin]. The increase of fatty acids in HFD feeding switches microglia fuel utilization toward fatty acids and enhances inflammatory responses in the hypothalamus. Cytokines released from microglia can affect neuronal activity (TNFa, IL-1b) as well as astrocytic activity (IL-1a, TNFa, C1q). Activated neurons, astrocytes, and microglia recruit CD169+ and CCR2+ peripheral myeloid cells in the hypothalamus via release of chemokies such as CX3CL1 and CCL2. AgRP, Agouti-related protein; POMC, proopiomelanocortin.
See this image and copyright information in PMC

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