Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 26;28(1):54-58.
doi: 10.5935/1518-0557.20230054.

Correlations between clinical parameters, blastocyst morphological classification and embryo euploidy

Juliano Brum Scheffer  1 , Rafaela Friche de Carvalho  1 , Bruno Brum Scheffer  1 , Ana Paula de Souza Aguiar  1 , Luiza Pinheiro Pessoa  1 , Daniel Mendez Lozano  2 , Renato Fanchin  3
Affiliations

Correlations between clinical parameters, blastocyst morphological classification and embryo euploidy

Juliano Brum Scheffer et al. JBRA Assist Reprod. .

Abstract

Objective: The aim of the present study was to evaluate clinical and embryo parameters to predict embryo ploidy.

Methods: In this retrospective analysis, we studied 838 biopsied day-5 blastocysts from 219 patients in the period from May 2021 to July 2022. All embryos were morphologically classified before biopsy and were divided into two groups according to genetic test results. Euploid embryos (299) were compared with aneuploid embryos (539) based on maternal age, anti-Mullerian hormone, antral follicle count, and embryo morphology.

Results: Maternal age (36.2±3.0) of euploid embryos was lower than maternal age (37.1±2.5) of aneuploid embryos (p<0.0001). AMH levels were higher (3.9±1.2) in the group of euploid embryos than in the group of aneuploid embryos (3.6±1.3, p<0.0001). However, the AFC was not different in the group of euploid embryos (15.3±6.0) compared to the group of aneuploid embryos (14.5±5.9, p=0.07). The presence of aneuploidy was negatively correlated with top embryo quality (embryos 4AA and 4AB). All euploid embryos (299) were top quality versus 331 of 539 (61.49%) aneuploid embryos (p<0.0001).

Conclusions: We found that euploid embryos were associated with lower maternal age, higher AMH levels, and higher quality embryos.

Keywords: AMH; PGT-A; age; aneuploidy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The mean maternal age of euploid embryos was lower than the mean maternal age of aneuploid embryos.
Figure 2
Figure 2
AMH levels (ng/mL) were higher in the group of euploid embryos than in the group of aneuploid embryos.
See this image and copyright information in PMC

References

    1. Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility - a clinician’s perspective. Reprod Biomed Online. 2005;11:641–650. doi: 10.1016/s1472-6483(10)61174-1. - DOI - PubMed
    1. Ahlström A, Westin C, Reismer E, Wikland M, Hardarson T. Trophectoderm morphology: an important parameter for predicting live birth after single blastocyst transfer. Hum Reprod. 2011;26:3289–3296. doi: 10.1093/humrep/der325. - DOI - PubMed
    1. Ahlström A, Westin C, Wikland M, Hardarson T. Prediction of live birth in frozen-thawed single blastocyst transfer cycles by pre-freeze and post-thaw morphology. Hum Reprod. 2013;28:1199–1209. doi: 10.1093/humrep/det054. - DOI - PubMed
    1. Alfarawati S, Fragouli E, Colls P, Stevens J, Gutiérrez-Mateo C, Schoolcraft WB, Katz-Jaffe MG, Wells D. The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender. Fertil Steril. 2011;95:520–524. doi: 10.1016/j.fertnstert.2010.04.003. - DOI - PubMed
    1. Almagor M, Harir Y, Fieldust S, Or Y, Shoham Z. Ratio between inner cell mass diameter and blastocyst diameter is correlated with successful pregnancy outcomes of single blastocyst transfers. Fertil Steril. 2016;106:1386–1391. doi: 10.1016/j.fertnstert.2016.08.009. - DOI - PubMed

Publication types